| http://purl.uniprot.org/citations/34257619 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34257619 | http://www.w3.org/2000/01/rdf-schema#comment | "Purpose: The Myc family, especially C-MYC and MYCL1, has been found involved in small-cell lung carcinoma (SCLC). Identification of the frequency of C-MYC and MYCL1 expression among SCLC patients may help to identify potential targets for therapeutic intervention. Our aim was to detect MYCL1 amplification, L-Myc and c-Myc expression, and investigate clinicopathological characteristics and survival status in patients with surgically resected SCLC. Methods: MYCL1 amplification was detected using fluorescence in situ hybridization (FISH), while L-Myc and c-Myc protein expressions were determined using immunohistochemistry (IHC) in the primary tumors of 46 resected SCLC patients. Results: Among the 46 evaluated specimens, MYCL1 amplification was identified in 3/46 cases (6.5%). One of the positive cases was MYCL1 gene amplification combined with fusion. 3/46 (6.5%) was positive for L-myc protein expression, and 4/46 (8.7%) was positive for c-Myc protein expression. Conclusion: Our study firstly multidimensional explored the expression of MYCL1 amplification, L-Myc and c-Myc protein and investigated clinicopathological characteristics and survival status in patients with surgically resected SCLC, which makes a contribution to subsequent research and therapeutic strategies."xsd:string |
| http://purl.uniprot.org/citations/34257619 | http://purl.org/dc/terms/identifier | "doi:10.3389/pore.2021.1609775"xsd:string |
| http://purl.uniprot.org/citations/34257619 | http://purl.uniprot.org/core/author | "Li C."xsd:string |
| http://purl.uniprot.org/citations/34257619 | http://purl.uniprot.org/core/author | "Lu H."xsd:string |
| http://purl.uniprot.org/citations/34257619 | http://purl.uniprot.org/core/author | "Qin J."xsd:string |
| http://purl.uniprot.org/citations/34257619 | http://purl.uniprot.org/core/author | "Xie F."xsd:string |
| http://purl.uniprot.org/citations/34257619 | http://purl.uniprot.org/core/author | "Han N."xsd:string |
| http://purl.uniprot.org/citations/34257619 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34257619 | http://purl.uniprot.org/core/name | "Pathol Oncol Res"xsd:string |
| http://purl.uniprot.org/citations/34257619 | http://purl.uniprot.org/core/pages | "1609775"xsd:string |
| http://purl.uniprot.org/citations/34257619 | http://purl.uniprot.org/core/title | "MYCL1 Amplification and Expression of L-Myc and c-Myc in Surgically Resected Small-Cell Lung Carcinoma."xsd:string |
| http://purl.uniprot.org/citations/34257619 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/34257619 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34257619 |
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