| http://purl.uniprot.org/citations/34260931 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34260931 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34260931 | http://www.w3.org/2000/01/rdf-schema#comment | "eIF5-mimic protein (5MP) is a translational regulatory protein that binds the small ribosomal subunit and modulates its activity. 5MP is proposed to reprogram non-AUG translation rates for oncogenes in cancer, but its role in controlling non-AUG initiated synthesis of deleterious repeat-peptide products, such as FMRpolyG observed in fragile-X-associated tremor ataxia syndrome (FXTAS), is unknown. Here, we show that 5MP can suppress both general and repeat-associated non-AUG (RAN) translation by a common mechanism in a manner dependent on its interaction with eIF3. Essentially, 5MP displaces eIF5 through the eIF3c subunit within the preinitiation complex (PIC), thereby increasing the accuracy of initiation. In Drosophila, 5MP/Kra represses neuronal toxicity and enhances the lifespan in an FXTAS disease model. These results implicate 5MP in protecting cells from unwanted byproducts of non-AUG translation in neurodegeneration."xsd:string |
| http://purl.uniprot.org/citations/34260931 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2021.109376"xsd:string |
| http://purl.uniprot.org/citations/34260931 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2021.109376"xsd:string |
| http://purl.uniprot.org/citations/34260931 | http://purl.uniprot.org/core/author | "Asano K."xsd:string |
| http://purl.uniprot.org/citations/34260931 | http://purl.uniprot.org/core/author | "Asano K."xsd:string |
| http://purl.uniprot.org/citations/34260931 | http://purl.uniprot.org/core/author | "Nakamura A."xsd:string |
| http://purl.uniprot.org/citations/34260931 | http://purl.uniprot.org/core/author | "Nakamura A."xsd:string |
| http://purl.uniprot.org/citations/34260931 | http://purl.uniprot.org/core/author | "Asano I."xsd:string |
| http://purl.uniprot.org/citations/34260931 | http://purl.uniprot.org/core/author | "Asano I."xsd:string |
| http://purl.uniprot.org/citations/34260931 | http://purl.uniprot.org/core/author | "Asano M."xsd:string |
| http://purl.uniprot.org/citations/34260931 | http://purl.uniprot.org/core/author | "Asano M."xsd:string |
| http://purl.uniprot.org/citations/34260931 | http://purl.uniprot.org/core/author | "Aube E."xsd:string |
| http://purl.uniprot.org/citations/34260931 | http://purl.uniprot.org/core/author | "Aube E."xsd:string |
| http://purl.uniprot.org/citations/34260931 | http://purl.uniprot.org/core/author | "Cecil A."xsd:string |
| http://purl.uniprot.org/citations/34260931 | http://purl.uniprot.org/core/author | "Cecil A."xsd:string |
| http://purl.uniprot.org/citations/34260931 | http://purl.uniprot.org/core/author | "Escalante C.R."xsd:string |
| http://purl.uniprot.org/citations/34260931 | http://purl.uniprot.org/core/author | "Escalante C.R."xsd:string |
| http://purl.uniprot.org/citations/34260931 | http://purl.uniprot.org/core/author | "Gillaspie S."xsd:string |
| http://purl.uniprot.org/citations/34260931 | http://purl.uniprot.org/core/author | "Gillaspie S."xsd:string |
| http://purl.uniprot.org/citations/34260931 | http://purl.uniprot.org/core/author | "Glineburg M.R."xsd:string |
| http://purl.uniprot.org/citations/34260931 | http://purl.uniprot.org/core/author | "Glineburg M.R."xsd:string |
| http://purl.uniprot.org/citations/34260931 | http://purl.uniprot.org/core/author | "Hilgers M."xsd:string |
| http://purl.uniprot.org/citations/34260931 | http://purl.uniprot.org/core/author | "Hilgers M."xsd:string |