| http://purl.uniprot.org/citations/34261699 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34261699 | http://www.w3.org/2000/01/rdf-schema#comment | "Eukaryotic cells maintain proteostasis through mechanisms that require cytoplasmic and mitochondrial translation. Genetic defects affecting cytoplasmic translation perturb synapse development, neurotransmission, and are causative of neurodevelopmental disorders, such as Fragile X syndrome. In contrast, there is little indication that mitochondrial proteostasis, either in the form of mitochondrial protein translation and/or degradation, is required for synapse development and function. Here we focus on two genes deleted in a recurrent copy number variation causing neurodevelopmental disorders, the 22q11.2 microdeletion syndrome. We demonstrate that SLC25A1 and MRPL40, two genes present in the microdeleted segment and whose products localize to mitochondria, interact and are necessary for mitochondrial ribosomal integrity and proteostasis. Our Drosophila studies show that mitochondrial ribosome function is necessary for synapse neurodevelopment, function, and behavior. We propose that mitochondrial proteostasis perturbations, either by genetic or environmental factors, are a pathogenic mechanism for neurodevelopmental disorders.SIGNIFICANCE STATEMENT The balance between cytoplasmic protein synthesis and degradation, or cytoplasmic proteostasis, is required for normal synapse function and neurodevelopment. Cytoplasmic and mitochondrial ribosomes are necessary for two compartmentalized, yet interdependent, forms of proteostasis. Proteostasis dependent on cytoplasmic ribosomes is a well-established target of genetic defects that cause neurodevelopmental disorders, such as autism. Here we show that the mitochondrial ribosome is a neurodevelopmentally regulated organelle whose function is required for synapse development and function. We propose that defective mitochondrial proteostasis is a mechanism with the potential to contribute to neurodevelopmental disease."xsd:string |
| http://purl.uniprot.org/citations/34261699 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.2197-20.2021"xsd:string |
| http://purl.uniprot.org/citations/34261699 | http://purl.uniprot.org/core/author | "Xu C."xsd:string |
| http://purl.uniprot.org/citations/34261699 | http://purl.uniprot.org/core/author | "Wen Z."xsd:string |
| http://purl.uniprot.org/citations/34261699 | http://purl.uniprot.org/core/author | "Lee C.E."xsd:string |
| http://purl.uniprot.org/citations/34261699 | http://purl.uniprot.org/core/author | "Werner E."xsd:string |
| http://purl.uniprot.org/citations/34261699 | http://purl.uniprot.org/core/author | "Faundez V."xsd:string |
| http://purl.uniprot.org/citations/34261699 | http://purl.uniprot.org/core/author | "Gokhale A."xsd:string |
| http://purl.uniprot.org/citations/34261699 | http://purl.uniprot.org/core/author | "Zlatic S.A."xsd:string |
| http://purl.uniprot.org/citations/34261699 | http://purl.uniprot.org/core/author | "Lewis D.A."xsd:string |
| http://purl.uniprot.org/citations/34261699 | http://purl.uniprot.org/core/author | "Duong D."xsd:string |
| http://purl.uniprot.org/citations/34261699 | http://purl.uniprot.org/core/author | "Hartwig C."xsd:string |
| http://purl.uniprot.org/citations/34261699 | http://purl.uniprot.org/core/author | "Seyfried N.T."xsd:string |
| http://purl.uniprot.org/citations/34261699 | http://purl.uniprot.org/core/author | "Freeman A.A.H."xsd:string |
| http://purl.uniprot.org/citations/34261699 | http://purl.uniprot.org/core/author | "Bearden C.E."xsd:string |
| http://purl.uniprot.org/citations/34261699 | http://purl.uniprot.org/core/author | "Glausier J.R."xsd:string |
| http://purl.uniprot.org/citations/34261699 | http://purl.uniprot.org/core/author | "Rowan M.J.M."xsd:string |
| http://purl.uniprot.org/citations/34261699 | http://purl.uniprot.org/core/author | "Bassell J.L."xsd:string |
| http://purl.uniprot.org/citations/34261699 | http://purl.uniprot.org/core/author | "Shearing N."xsd:string |
| http://purl.uniprot.org/citations/34261699 | http://purl.uniprot.org/core/author | "Ogunbona O."xsd:string |
| http://purl.uniprot.org/citations/34261699 | http://purl.uniprot.org/core/author | "Olah V.J."xsd:string |
| http://purl.uniprot.org/citations/34261699 | http://purl.uniprot.org/core/author | "Wynne M.E."xsd:string |
| http://purl.uniprot.org/citations/34261699 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34261699 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |