| http://purl.uniprot.org/citations/34268577 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34268577 | http://www.w3.org/2000/01/rdf-schema#comment | "In eukaryotes, three RNA polymerases (RNAPs) play essential roles in the synthesis of various types of RNA: namely, RNAPI for rRNA; RNAPII for mRNA and most snRNAs; and RNAPIII for tRNA and other small RNAs. All three RNAPs possess a short flexible tail derived from their common subunit RPB6. However, the function of this shared N-terminal tail (NTT) is not clear. Here we show that NTT interacts with the PH domain (PH-D) of the p62 subunit of the general transcription/repair factor TFIIH, and present the structures of RPB6 unbound and bound to PH-D by nuclear magnetic resonance (NMR). Using available cryo-EM structures, we modelled the activated elongation complex of RNAPII bound to TFIIH. We also provide evidence that the recruitment of TFIIH to transcription sites through the p62-RPB6 interaction is a common mechanism for transcription-coupled nucleotide excision repair (TC-NER) of RNAPI- and RNAPII-transcribed genes. Moreover, point mutations in the RPB6 NTT cause a significant reduction in transcription of RNAPI-, RNAPII- and RNAPIII-transcribed genes. These and other results show that the p62-RPB6 interaction plays multiple roles in transcription, TC-NER, and cell proliferation, suggesting that TFIIH is engaged in all RNAP systems."xsd:string |
| http://purl.uniprot.org/citations/34268577 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gkab612"xsd:string |
| http://purl.uniprot.org/citations/34268577 | http://purl.uniprot.org/core/author | "Nishimura Y."xsd:string |
| http://purl.uniprot.org/citations/34268577 | http://purl.uniprot.org/core/author | "Suzuki H."xsd:string |
| http://purl.uniprot.org/citations/34268577 | http://purl.uniprot.org/core/author | "Suwa T."xsd:string |
| http://purl.uniprot.org/citations/34268577 | http://purl.uniprot.org/core/author | "Yamaguchi Y."xsd:string |
| http://purl.uniprot.org/citations/34268577 | http://purl.uniprot.org/core/author | "Okuda M."xsd:string |
| http://purl.uniprot.org/citations/34268577 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/34268577 | http://purl.uniprot.org/core/name | "Nucleic Acids Res"xsd:string |
| http://purl.uniprot.org/citations/34268577 | http://purl.uniprot.org/core/pages | "1-16"xsd:string |
| http://purl.uniprot.org/citations/34268577 | http://purl.uniprot.org/core/title | "Three human RNA polymerases interact with TFIIH via a common RPB6 subunit."xsd:string |
| http://purl.uniprot.org/citations/34268577 | http://purl.uniprot.org/core/volume | "50"xsd:string |
| http://purl.uniprot.org/citations/34268577 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34268577 |
| http://purl.uniprot.org/citations/34268577 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34268577 |
| http://purl.uniprot.org/uniprot/#_A0A384MTQ8-mappedCitation-34268577 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34268577 |
| http://purl.uniprot.org/uniprot/#_B0QYL9-mappedCitation-34268577 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34268577 |
| http://purl.uniprot.org/uniprot/#_B2R7G4-mappedCitation-34268577 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34268577 |
| http://purl.uniprot.org/uniprot/#_B4DSG6-mappedCitation-34268577 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34268577 |
| http://purl.uniprot.org/uniprot/#_B2R4H6-mappedCitation-34268577 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34268577 |
| http://purl.uniprot.org/uniprot/#_B4DS87-mappedCitation-34268577 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34268577 |
| http://purl.uniprot.org/uniprot/#_P32780-mappedCitation-34268577 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34268577 |
| http://purl.uniprot.org/uniprot/#_P61218-mappedCitation-34268577 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34268577 |
| http://purl.uniprot.org/uniprot/#_Q8N7A7-mappedCitation-34268577 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34268577 |
| http://purl.uniprot.org/uniprot/B4DSG6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/34268577 |