| http://purl.uniprot.org/citations/34270547 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34270547 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundPlasmodium vivax occurs as a latent infection of liver and a patent infection of red blood cells. Radical cure requires both blood schizontocidal and hypnozoitocidal chemotherapies. The hypnozoitocidal therapies available are primaquine and tafenoquine, 8-aminoquinoline drugs that can provoke threatening acute hemolytic anemia in patients having an X-linked G6PD-deficiency. Heterozygous females may screen as G6PD-normal prior to radical cure and go on to experience hemolytic crisis.Methods & findingsThis study examined G6PD phenotypes in 1928 female subjects living in malarious Sumba Island in eastern Indonesia to ascertain the prevalence of females vulnerable to diagnostic misclassification as G6PD-normal. All 367 (19%) females having <80% G6PD normal activity were genotyped. Among those, 103 (28%) were G6PD wild type, 251 (68·4%) were heterozygous, three (0·8%) were compound heterozygotes, and ten (2·7%) were homozygous deficient. The variants Vanua Lava, Viangchan, Coimbra, Chatham, and Kaiping occurred among them. Below the 70% of normal G6PD activity threshold, just 18 (8%) were G6PD-normal and 214 (92%) were G6PD-deficient. Among the 31 females with <30% G6PD normal activity were all ten homozygotes, all three compound heterozygotes, and just 18 were heterozygotes (7% of those).ConclusionsIn this population, most G6PD heterozygosity in females occurred between 30% and 70% of normal (69·3%; 183/264). The prevalence of females at risk of G6PD misclassification as normal by qualitative screening was 9·5% (183/1928). Qualitative G6PD screening prior to 8-aminoquinoline therapies against P. vivax may leave one in ten females at risk of hemolytic crisis, which may be remedied by point-of-care quantitative tests."xsd:string |
| http://purl.uniprot.org/citations/34270547 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pntd.0009610"xsd:string |
| http://purl.uniprot.org/citations/34270547 | http://purl.uniprot.org/core/author | "Baird J.K."xsd:string |
| http://purl.uniprot.org/citations/34270547 | http://purl.uniprot.org/core/author | "Panggalo L.V."xsd:string |
| http://purl.uniprot.org/citations/34270547 | http://purl.uniprot.org/core/author | "Satyagraha A.W."xsd:string |
| http://purl.uniprot.org/citations/34270547 | http://purl.uniprot.org/core/author | "Harahap A.R."xsd:string |
| http://purl.uniprot.org/citations/34270547 | http://purl.uniprot.org/core/author | "Subekti D."xsd:string |
| http://purl.uniprot.org/citations/34270547 | http://purl.uniprot.org/core/author | "Elyazar I."xsd:string |
| http://purl.uniprot.org/citations/34270547 | http://purl.uniprot.org/core/author | "Mahpud N."xsd:string |
| http://purl.uniprot.org/citations/34270547 | http://purl.uniprot.org/core/author | "Sadhewa A."xsd:string |
| http://purl.uniprot.org/citations/34270547 | http://purl.uniprot.org/core/author | "Soebianto S."xsd:string |
| http://purl.uniprot.org/citations/34270547 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34270547 | http://purl.uniprot.org/core/name | "PLoS Negl Trop Dis"xsd:string |
| http://purl.uniprot.org/citations/34270547 | http://purl.uniprot.org/core/pages | "e0009610"xsd:string |
| http://purl.uniprot.org/citations/34270547 | http://purl.uniprot.org/core/title | "Genotypes and phenotypes of G6PD deficiency among Indonesian females across diagnostic thresholds of G6PD activity guiding safe primaquine therapy of latent malaria."xsd:string |
| http://purl.uniprot.org/citations/34270547 | http://purl.uniprot.org/core/volume | "15"xsd:string |
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