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http://purl.uniprot.org/citations/34271514http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
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Backgrounds

Although evidence suggests that the activity of the anterior cingulate cortex involves social cognition, there are inconsistent findings regarding the aberrant cingulate gray matter (GM) and scanty evidence about altered cortical thickness and white matter (WM) of cingulate in individuals with autism spectrum disorder (ASD). Evidence supports the association between the genetic variants of CNTNAP2 and altered brain connectivity. This study investigated the cingulate substructure and its association with social awareness deficits and the CNTNAP2 variants in individuals with ASD and typically-developing controls (TDC).

Methods

We assessed 118 individuals with ASD and 122 TDC with MRI and clinical evaluation. The GM, WM volumes and cortical thickness of the cingulate gyrus were compared between ASD and TDC based on fine parcellation. Five SNPs of the CNTNAP2 linked to ASD and brain structural abnormality were genotyped, and rs2710102, rs2538991, rs2710126 passed quality control filters.

Results

ASD individuals showed thinner cortical thickness in bilateral cingulate subregions than TDC without significant group differences in GM and WM volumes. The WM volume of the right anterior cingulate gyrus was correlated with social awareness deficits in ASD. The CNTNAP2 variant demonstrated a main effect on the WM volumes of the right middle cingulate gyrus. Besides, the CNTNAP2 variants interacted with ASD diagnosis and age on the cortical thickness of the left anterior middle cingulate cortex.

Conclusions

Our findings suggest that aberrant cingulate structure in ASD might be associated with the social awareness deficits and genetic variants of the CNTNAP2. These novel findings need validation."xsd:string
http://purl.uniprot.org/citations/34271514http://purl.org/dc/terms/identifier"doi:10.1016/j.nicl.2021.102729"xsd:string
http://purl.uniprot.org/citations/34271514http://purl.uniprot.org/core/author"Chen Y.C."xsd:string
http://purl.uniprot.org/citations/34271514http://purl.uniprot.org/core/author"Chien Y.L."xsd:string
http://purl.uniprot.org/citations/34271514http://purl.uniprot.org/core/author"Gau S.S."xsd:string
http://purl.uniprot.org/citations/34271514http://purl.uniprot.org/core/date"2021"xsd:gYear
http://purl.uniprot.org/citations/34271514http://purl.uniprot.org/core/name"Neuroimage Clin"xsd:string
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http://purl.uniprot.org/citations/34271514http://purl.uniprot.org/core/title"Altered cingulate structures and the associations with social awareness deficits and CNTNAP2 gene in autism spectrum disorder."xsd:string
http://purl.uniprot.org/citations/34271514http://purl.uniprot.org/core/volume"31"xsd:string
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