| http://purl.uniprot.org/citations/34272244 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34272244 | http://www.w3.org/2000/01/rdf-schema#comment | "The mechanisms maintaining adult lymphatic vascular specialization throughout life and their role in coordinating inter-organ communication to sustain homeostasis remain elusive. We report that inactivation of the mechanosensitive transcription factor Foxc2 in adult lymphatic endothelium leads to a stepwise intestine-to-lung systemic failure. Foxc2 loss compromised the gut epithelial barrier, promoted dysbiosis and bacterial translocation to peripheral lymph nodes, and increased circulating levels of purine metabolites and angiopoietin-2. Commensal microbiota depletion dampened systemic pro-inflammatory cytokine levels, corrected intestinal lymphatic dysfunction, and improved survival. Foxc2 loss skewed the specialization of lymphatic endothelial subsets, leading to populations with mixed, pro-fibrotic identities and to emergence of lymph node-like endothelial cells. Our study uncovers a cross-talk between lymphatic vascular function and commensal microbiota, provides single-cell atlas of lymphatic endothelial subtypes, and reveals organ-specific and systemic effects of dysfunctional lymphatics. These effects potentially contribute to the pathogenesis of diseases, such as inflammatory bowel disease, cancer, or lymphedema."xsd:string |
| http://purl.uniprot.org/citations/34272244 | http://purl.org/dc/terms/identifier | "doi:10.1126/sciadv.abf4335"xsd:string |
| http://purl.uniprot.org/citations/34272244 | http://purl.uniprot.org/core/author | "Kim J."xsd:string |
| http://purl.uniprot.org/citations/34272244 | http://purl.uniprot.org/core/author | "Delorenzi M."xsd:string |
| http://purl.uniprot.org/citations/34272244 | http://purl.uniprot.org/core/author | "Zamboni N."xsd:string |
| http://purl.uniprot.org/citations/34272244 | http://purl.uniprot.org/core/author | "Guarda G."xsd:string |
| http://purl.uniprot.org/citations/34272244 | http://purl.uniprot.org/core/author | "Luther S.A."xsd:string |
| http://purl.uniprot.org/citations/34272244 | http://purl.uniprot.org/core/author | "Petrova T.V."xsd:string |
| http://purl.uniprot.org/citations/34272244 | http://purl.uniprot.org/core/author | "Rota G."xsd:string |
| http://purl.uniprot.org/citations/34272244 | http://purl.uniprot.org/core/author | "Sabine A."xsd:string |
| http://purl.uniprot.org/citations/34272244 | http://purl.uniprot.org/core/author | "Marsland B."xsd:string |
| http://purl.uniprot.org/citations/34272244 | http://purl.uniprot.org/core/author | "Velin D."xsd:string |
| http://purl.uniprot.org/citations/34272244 | http://purl.uniprot.org/core/author | "Gonzalez-Loyola A."xsd:string |
| http://purl.uniprot.org/citations/34272244 | http://purl.uniprot.org/core/author | "Arroz-Madeira S."xsd:string |
| http://purl.uniprot.org/citations/34272244 | http://purl.uniprot.org/core/author | "Bovay E."xsd:string |
| http://purl.uniprot.org/citations/34272244 | http://purl.uniprot.org/core/author | "Rapin A."xsd:string |
| http://purl.uniprot.org/citations/34272244 | http://purl.uniprot.org/core/author | "Durot S."xsd:string |
| http://purl.uniprot.org/citations/34272244 | http://purl.uniprot.org/core/author | "Lozano T.W."xsd:string |
| http://purl.uniprot.org/citations/34272244 | http://purl.uniprot.org/core/author | "Renevey F."xsd:string |
| http://purl.uniprot.org/citations/34272244 | http://purl.uniprot.org/core/author | "Wypych T.P."xsd:string |
| http://purl.uniprot.org/citations/34272244 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34272244 | http://purl.uniprot.org/core/name | "Sci Adv"xsd:string |
| http://purl.uniprot.org/citations/34272244 | http://purl.uniprot.org/core/pages | "eabf4335"xsd:string |
| http://purl.uniprot.org/citations/34272244 | http://purl.uniprot.org/core/title | "FOXC2 controls adult lymphatic endothelial specialization, function, and gut lymphatic barrier preventing multiorgan failure."xsd:string |