| http://purl.uniprot.org/citations/34278939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34278939 | http://www.w3.org/2000/01/rdf-schema#comment | "Hypersynchronous neural activity is a characteristic feature of seizures. Although many Drosophila mutants of epilepsy-related genes display clear behavioral spasms and motor unit hyperexcitability, field potential measurements of aberrant hypersynchronous activity across brain regions during seizures have yet to be described. Here, we report a straightforward method to observe local field potentials (LFPs) from the Drosophila brain to monitor ensemble neural activity during seizures in behaving tethered flies. High frequency stimulation across the brain reliably triggers a stereotypic sequence of electroconvulsive seizure (ECS) spike discharges readily detectable in the dorsal longitudinal muscle (DLM) and coupled with behavioral spasms. During seizure episodes, the LFP signal displayed characteristic large-amplitude oscillations with a stereotypic temporal correlation to DLM flight muscle spiking. ECS-related LFP events were clearly distinct from rest- and flight-associated LFP patterns. We further characterized the LFP activity during different types of seizures originating from genetic and pharmacological manipulations. In the 'bang-sensitive' sodium channel mutant bangsenseless (bss), the LFP pattern was prolonged, and the temporal correlation between LFP oscillations and DLM discharges was altered. Following administration of the pro-convulsant GABAA blocker picrotoxin, we uncovered a qualitatively different LFP activity pattern, which consisted of a slow (1-Hz), repetitive, waveform, closely coupled with DLM bursting and behavioral spasms. Our approach to record brain LFPs presents an initial framework for electrophysiological analysis of the complex brain-wide activity patterns in the large collection of Drosophila excitability mutants."xsd:string |
| http://purl.uniprot.org/citations/34278939 | http://purl.org/dc/terms/identifier | "doi:10.1080/01677063.2021.1950714"xsd:string |
| http://purl.uniprot.org/citations/34278939 | http://purl.uniprot.org/core/author | "Wu C.F."xsd:string |
| http://purl.uniprot.org/citations/34278939 | http://purl.uniprot.org/core/author | "Iyengar A."xsd:string |
| http://purl.uniprot.org/citations/34278939 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34278939 | http://purl.uniprot.org/core/name | "J Neurogenet"xsd:string |
| http://purl.uniprot.org/citations/34278939 | http://purl.uniprot.org/core/pages | "295-305"xsd:string |
| http://purl.uniprot.org/citations/34278939 | http://purl.uniprot.org/core/title | "Fly seizure EEG: field potential activity in the Drosophila brain."xsd:string |
| http://purl.uniprot.org/citations/34278939 | http://purl.uniprot.org/core/volume | "35"xsd:string |
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| http://purl.uniprot.org/uniprot/#_M9MSP4-mappedCitation-34278939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34278939 |
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| http://purl.uniprot.org/uniprot/#_M9MSP6-mappedCitation-34278939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34278939 |