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http://purl.uniprot.org/citations/34279801http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/34279801http://www.w3.org/2000/01/rdf-schema#comment"

Background

Several studies have evaluated the possible association between polymorphisms or variants in Corticotropin-releasing hormone 1 receptor gene (CRHR1) with depression; however, results remain contradictory and heterogeneous.

Objective

To our knowledge, we conducted the first comprehensive systematic review and meta-analysis evaluating the association of the CRHR1 gene and the risk of depression.

Methods

A search online was conducted in databases for any CRHR1 genetic association studies in depression. Data were extracted for evaluation of pooled estimates using meta-analytic techniques. Statistical analyses were performed using the Comprehensive Meta-analysis, v2.0 software.

Result

A total of 1403 cases and 2353 mentally healthy controls were included in this study. We found a significant association of rs242941, rs1876828 and rs242939 variants of the CRHR1 gene with depression. No association of CRHR1 rs110402 and depression was observed.

Conclusion

Our meta-analysis shows that some variants of the CRHR1 gene (rs242941, rs1876828 and rs242939) might confer susceptibility to depression. Further studies with larger sample sizes need to be conducted."xsd:string
http://purl.uniprot.org/citations/34279801http://purl.org/dc/terms/identifier"doi:10.1007/s13258-021-01133-9"xsd:string
http://purl.uniprot.org/citations/34279801http://purl.uniprot.org/core/author"Fresan A."xsd:string
http://purl.uniprot.org/citations/34279801http://purl.uniprot.org/core/author"Nicolini H."xsd:string
http://purl.uniprot.org/citations/34279801http://purl.uniprot.org/core/author"Juarez-Rojop I.E."xsd:string
http://purl.uniprot.org/citations/34279801http://purl.uniprot.org/core/author"Gonzalez-Castro T.B."xsd:string
http://purl.uniprot.org/citations/34279801http://purl.uniprot.org/core/author"Tovilla-Zarate C.A."xsd:string
http://purl.uniprot.org/citations/34279801http://purl.uniprot.org/core/author"Lopez-Narvaez M.L."xsd:string
http://purl.uniprot.org/citations/34279801http://purl.uniprot.org/core/author"Hernandez-Diaz Y."xsd:string
http://purl.uniprot.org/citations/34279801http://purl.uniprot.org/core/author"Genis-Mendoza A.D."xsd:string
http://purl.uniprot.org/citations/34279801http://purl.uniprot.org/core/date"2021"xsd:gYear
http://purl.uniprot.org/citations/34279801http://purl.uniprot.org/core/name"Genes Genomics"xsd:string
http://purl.uniprot.org/citations/34279801http://purl.uniprot.org/core/pages"1339-1349"xsd:string
http://purl.uniprot.org/citations/34279801http://purl.uniprot.org/core/title"The role of rs242941, rs1876828, rs242939 and rs110402 polymorphisms of CRHR1 gene and the depression: systematic review and meta-analysis."xsd:string
http://purl.uniprot.org/citations/34279801http://purl.uniprot.org/core/volume"43"xsd:string
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