| http://purl.uniprot.org/citations/34280008 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34280008 | http://www.w3.org/2000/01/rdf-schema#comment | "Background: B7-H6, a newly discovered member of the immunoglobulin superfamily, exerts antitumor effects by binding to NKP30 receptor on natural killer cells; it has important clinical implications. Cell surface ectodomain shedding of B7-H6 generates soluble B7-H6 (sB7-H6), which is highly expressed and serves as a valuable biomarker in multiple tumors, but the clinical significance and diagnostic value of B7-H6 in cervical squamous cell carcinoma (CSCC) remains unclear. Objective: To assess the expression and diagnostic value of B7-H6 in CSCC. Methods: In this study, 69 cervical specimens were analyzed for B7-H6 expression: 25 paired CSCC tissues were examined using quantitative real-time polymerase chain reaction, and 24 paraffin-embedded CSCC tissues and 20 normal tissues were analyzed immunohistochemically. Furthermore, plasma samples from 30 CSCC patients and 24 healthy controls were examined using ELISA. Results: B7-H6 mRNA and protein levels were significantly higher in CSCC tissues than in adjacent normal cervical tissues (p < 0.05). Immunohistochemical analysis revealed that high B7-H6 expression correlated with stromal invasion (p = 0.043), lymphovascular space involvement (p = 0.005), lymph node metastasis (p = 0.019), and International Federation of Gynecology and Obstetrics (FIGO) stage (p = 0.002). Moreover, ELISA results demonstrated that the sB7-H6 concentration in peripheral blood was higher in CSCC patients than in healthy controls (p < 0.0001). Notably, at the optimal cutoff point of 0.076 ng/mL, sB7-H6 showed 93.3% sensitivity and 62.5% specificity in the discrimination of CSCC patients from healthy controls. Conclusions: B7-H6 mRNA and protein levels are markedly increased in CSCC tissues and peripheral blood samples, and the B7-H6 level can be used as a biomarker for predicting the severity of CSCC disease and discriminating CSCC patients from healthy controls."xsd:string |
| http://purl.uniprot.org/citations/34280008 | http://purl.org/dc/terms/identifier | "doi:10.1089/gtmb.2020.0313"xsd:string |
| http://purl.uniprot.org/citations/34280008 | http://purl.uniprot.org/core/author | "Guo R."xsd:string |
| http://purl.uniprot.org/citations/34280008 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/34280008 | http://purl.uniprot.org/core/author | "Xu Y."xsd:string |
| http://purl.uniprot.org/citations/34280008 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34280008 | http://purl.uniprot.org/core/name | "Genet Test Mol Biomarkers"xsd:string |
| http://purl.uniprot.org/citations/34280008 | http://purl.uniprot.org/core/pages | "463-470"xsd:string |
| http://purl.uniprot.org/citations/34280008 | http://purl.uniprot.org/core/title | "B7-H6 as a Diagnostic Biomarker for Cervical Squamous Cell Carcinoma."xsd:string |
| http://purl.uniprot.org/citations/34280008 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/34280008 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34280008 |
| http://purl.uniprot.org/citations/34280008 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34280008 |
| http://purl.uniprot.org/uniprot/#_Q68D85-mappedCitation-34280008 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34280008 |
| http://purl.uniprot.org/uniprot/Q68D85 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/34280008 |