| http://purl.uniprot.org/citations/34289356 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34289356 | http://www.w3.org/2000/01/rdf-schema#comment | "While the intrinsic apoptosis pathway is thought to play a central role in shaping the B cell lineage, its precise role in mature B cell homeostasis remains elusive. Using mice in which mature B cells are unable to undergo apoptotic cell death, we show that apoptosis constrains follicular B (FoB) cell lifespan but plays no role in marginal zone B (MZB) cell homeostasis. In these mice, FoB cells accumulate abnormally. This intensifies intercellular competition for BAFF, resulting in a contraction of the MZB cell compartment, and reducing the growth, trafficking, and fitness of FoB cells. Diminished BAFF signaling dampens the non-canonical NF-κB pathway, undermining FoB cell growth despite the concurrent triggering of a protective p53 response. Thus, MZB and FoB cells exhibit a differential requirement for the intrinsic apoptosis pathway. Homeostatic apoptosis constrains the size of the FoB cell compartment, thereby preventing competition-induced FoB cell atrophy."xsd:string |
| http://purl.uniprot.org/citations/34289356 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2021.109430"xsd:string |
| http://purl.uniprot.org/citations/34289356 | http://purl.uniprot.org/core/author | "Kile B.T."xsd:string |
| http://purl.uniprot.org/citations/34289356 | http://purl.uniprot.org/core/author | "Lane R.M."xsd:string |
| http://purl.uniprot.org/citations/34289356 | http://purl.uniprot.org/core/author | "Strasser A."xsd:string |
| http://purl.uniprot.org/citations/34289356 | http://purl.uniprot.org/core/author | "McArthur K."xsd:string |
| http://purl.uniprot.org/citations/34289356 | http://purl.uniprot.org/core/author | "Ritchie M.E."xsd:string |
| http://purl.uniprot.org/citations/34289356 | http://purl.uniprot.org/core/author | "Chappaz S."xsd:string |
| http://purl.uniprot.org/citations/34289356 | http://purl.uniprot.org/core/author | "Tailler M."xsd:string |
| http://purl.uniprot.org/citations/34289356 | http://purl.uniprot.org/core/author | "Good-Jacobson K.L."xsd:string |
| http://purl.uniprot.org/citations/34289356 | http://purl.uniprot.org/core/author | "Law C.W."xsd:string |
| http://purl.uniprot.org/citations/34289356 | http://purl.uniprot.org/core/author | "Kealy L."xsd:string |
| http://purl.uniprot.org/citations/34289356 | http://purl.uniprot.org/core/author | "Lieschke A."xsd:string |
| http://purl.uniprot.org/citations/34289356 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34289356 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/34289356 | http://purl.uniprot.org/core/pages | "109430"xsd:string |
| http://purl.uniprot.org/citations/34289356 | http://purl.uniprot.org/core/title | "Homeostatic apoptosis prevents competition-induced atrophy in follicular B cells."xsd:string |
| http://purl.uniprot.org/citations/34289356 | http://purl.uniprot.org/core/volume | "36"xsd:string |
| http://purl.uniprot.org/citations/34289356 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34289356 |
| http://purl.uniprot.org/citations/34289356 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34289356 |
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| http://purl.uniprot.org/uniprot/#_A0A0U1RPG0-mappedCitation-34289356 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34289356 |
| http://purl.uniprot.org/uniprot/#_Q07813-mappedCitation-34289356 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34289356 |
| http://purl.uniprot.org/uniprot/#_A0A140LI24-mappedCitation-34289356 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34289356 |