| http://purl.uniprot.org/citations/34290295 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34290295 | http://www.w3.org/2000/01/rdf-schema#comment | "Coagulation factors are produced from hepatocytes, whereas production of coagulation factor VIII (FVIII) from primary tissues and cell species is still controversial. Here, we tried to characterize primary FVIII-producing organ and cell species using genetically engineered mice, in which enhanced green fluorescent protein (EGFP) was expressed instead of the F8 gene. EGFP-positive FVIII-producing cells existed only in thin sinusoidal layer of the liver and characterized as CD31high, CD146high, and lymphatic vascular endothelial hyaluronan receptor 1 (Lyve1)+. EGFP-positive cells can be clearly distinguished from lymphatic endothelial cells in the expression profile of the podoplanin- and C-type lectin-like receptor-2 (CLEC-2)+. In embryogenesis, EGFP-positive cells began to emerge at E14.5 and subsequently increased according to liver maturation. Furthermore, plasma FVIII could be abolished by crossing F8 conditional deficient mice with Lyve1-Cre mice. In conclusion, in mice, FVIII is only produced from endothelial cells exhibiting CD31high, CD146high, Lyve1+, CLEC-2+, and podoplanin- in liver sinusoidal endothelial cells."xsd:string |
| http://purl.uniprot.org/citations/34290295 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-021-94307-0"xsd:string |
| http://purl.uniprot.org/citations/34290295 | http://purl.uniprot.org/core/author | "Ohmori T."xsd:string |
| http://purl.uniprot.org/citations/34290295 | http://purl.uniprot.org/core/author | "Matsumoto H."xsd:string |
| http://purl.uniprot.org/citations/34290295 | http://purl.uniprot.org/core/author | "Hayakawa M."xsd:string |
| http://purl.uniprot.org/citations/34290295 | http://purl.uniprot.org/core/author | "Sakata A."xsd:string |
| http://purl.uniprot.org/citations/34290295 | http://purl.uniprot.org/core/author | "Sakata Y."xsd:string |
| http://purl.uniprot.org/citations/34290295 | http://purl.uniprot.org/core/author | "Hayakawa H."xsd:string |
| http://purl.uniprot.org/citations/34290295 | http://purl.uniprot.org/core/author | "Suzuki-Inoue K."xsd:string |
| http://purl.uniprot.org/citations/34290295 | http://purl.uniprot.org/core/author | "Fukushima N."xsd:string |
| http://purl.uniprot.org/citations/34290295 | http://purl.uniprot.org/core/author | "Hiramoto T."xsd:string |
| http://purl.uniprot.org/citations/34290295 | http://purl.uniprot.org/core/author | "Kashiwakura Y."xsd:string |
| http://purl.uniprot.org/citations/34290295 | http://purl.uniprot.org/core/author | "Baatartsogt N."xsd:string |
| http://purl.uniprot.org/citations/34290295 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34290295 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/34290295 | http://purl.uniprot.org/core/pages | "14824"xsd:string |
| http://purl.uniprot.org/citations/34290295 | http://purl.uniprot.org/core/title | "Characterization and visualization of murine coagulation factor VIII-producing cells in vivo."xsd:string |
| http://purl.uniprot.org/citations/34290295 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/34290295 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34290295 |
| http://purl.uniprot.org/citations/34290295 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34290295 |
| http://purl.uniprot.org/uniprot/#_D3YW61-mappedCitation-34290295 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34290295 |
| http://purl.uniprot.org/uniprot/#_B2RRC9-mappedCitation-34290295 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34290295 |
| http://purl.uniprot.org/uniprot/#_B1AW26-mappedCitation-34290295 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34290295 |
| http://purl.uniprot.org/uniprot/#_B7ZNH8-mappedCitation-34290295 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34290295 |