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http://purl.uniprot.org/citations/34302635http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
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Background

Ovarian cancer is the most common female gynecological malignancy. SNHG20, as a long non-coding RNA, has been proven to be an important regulator in the occurrence and development of various tumors. However, the potential mechanism of SNHG20 in ovarian cancer is unclear.

Objective

The present study was aimed to investigate the functions and mechanisms of SNHG20 in ovarian cancer.

Methods

The expression of SNHG20 and miR-217 in ovarian cancer tissues and cell lines was detected by qRT-PCR. CCK-8 assay was used to measure cell proliferation in transfected cells. The transwell assay was used to detect the relative invasion rate of transfected cells. The putative binding sites between SNHG20 and miR-217 were predicted by software LncBase v.2, and the interaction between SNHG20 and miR-217 was confirmed by dual-luciferase reporter assays and RIP assay. The rescue experiments were used to illustrate potential mechanisms.

Results

SNHG20 was upregulated in ovarian cancer tissues and cell lines. Overexpression of SNHG20 promoted ovarian cancer cell proliferation and invasion. MiR-217 was downregulated in ovarian cancer tissues and cells, and was negatively regulated by SNHG20. Moreover, miR-217 overexpression inhibited ovarian cancer cell proliferation and invasion. Furthermore, miR-217 mimic reversed the inhibitory effect of SNHG20 overexpression on the biological behavior of ovarian cancer cells.

Conclusions

SNHG20 promoted cell proliferation and invasion by sponging miR-217 in ovarian cancer. These results suggested that SNHG20 and miR-217 might provide new targets for therapeutic application in ovarian cancer."xsd:string
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http://purl.uniprot.org/citations/34302635http://purl.uniprot.org/core/author"Chen T."xsd:string
http://purl.uniprot.org/citations/34302635http://purl.uniprot.org/core/author"Xing X."xsd:string
http://purl.uniprot.org/citations/34302635http://purl.uniprot.org/core/author"An M."xsd:string
http://purl.uniprot.org/citations/34302635http://purl.uniprot.org/core/date"2021"xsd:gYear
http://purl.uniprot.org/citations/34302635http://purl.uniprot.org/core/name"Genes Genomics"xsd:string
http://purl.uniprot.org/citations/34302635http://purl.uniprot.org/core/pages"1095-1104"xsd:string
http://purl.uniprot.org/citations/34302635http://purl.uniprot.org/core/title"LncRNA SNHG20 promotes cell proliferation and invasion by suppressing miR-217 in ovarian cancer."xsd:string
http://purl.uniprot.org/citations/34302635http://purl.uniprot.org/core/volume"43"xsd:string
http://purl.uniprot.org/citations/34302635http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/34302635
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