| http://purl.uniprot.org/citations/34315815 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34315815 | http://www.w3.org/2000/01/rdf-schema#comment | "The transcriptional induction of interferon (IFN) genes is a key feature of the mammalian antiviral response that limits viral replication and dissemination. A hallmark of severe COVID-19 disease caused by SARS-CoV-2 is the low presence of IFN proteins in patient serum despite elevated levels of IFN-encoding mRNAs, indicative of post-transcriptional inhibition of IFN protein production. Here, we performed single-molecule RNA visualization to examine the expression and localization of host mRNAs during SARS-CoV-2 infection. Our data show that the biogenesis of type I and type III IFN mRNAs is inhibited at multiple steps during SARS-CoV-2 infection. First, translocation of the interferon regulatory factor 3 (IRF3) transcription factor to the nucleus is limited in response to SARS-CoV-2, indicating that SARS-CoV-2 inhibits RLR-MAVS signaling and thus weakens transcriptional induction of IFN genes. Second, we observed that IFN mRNAs primarily localize to the site of transcription in most SARS-CoV-2 infected cells, suggesting that SARS-CoV-2 either inhibits the release of IFN mRNAs from their sites of transcription and/or triggers decay of IFN mRNAs in the nucleus upon exiting the site of transcription. Lastly, nuclear-cytoplasmic transport of IFN mRNAs is inhibited during SARS-CoV-2 infection, which we propose is a consequence of widespread degradation of host cytoplasmic basal mRNAs in the early stages of SARS-CoV-2 replication by the SARS-CoV-2 Nsp1 protein, as well as the host antiviral endoribonuclease, RNase L. Importantly, IFN mRNAs can escape SARS-CoV-2-mediated degradation if they reach the cytoplasm, making rescue of mRNA export a viable means for promoting the immune response to SARS-CoV-2."xsd:string |
| http://purl.uniprot.org/citations/34315815 | http://purl.org/dc/terms/identifier | "doi:10.1261/rna.078923.121"xsd:string |
| http://purl.uniprot.org/citations/34315815 | http://purl.uniprot.org/core/author | "Parker R."xsd:string |
| http://purl.uniprot.org/citations/34315815 | http://purl.uniprot.org/core/author | "Burke J.M."xsd:string |
| http://purl.uniprot.org/citations/34315815 | http://purl.uniprot.org/core/author | "Perera R."xsd:string |
| http://purl.uniprot.org/citations/34315815 | http://purl.uniprot.org/core/author | "St Clair L.A."xsd:string |
| http://purl.uniprot.org/citations/34315815 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34315815 | http://purl.uniprot.org/core/name | "RNA"xsd:string |
| http://purl.uniprot.org/citations/34315815 | http://purl.uniprot.org/core/pages | "1318-1329"xsd:string |
| http://purl.uniprot.org/citations/34315815 | http://purl.uniprot.org/core/title | "SARS-CoV-2 infection triggers widespread host mRNA decay leading to an mRNA export block."xsd:string |
| http://purl.uniprot.org/citations/34315815 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/34315815 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34315815 |
| http://purl.uniprot.org/citations/34315815 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34315815 |
| http://purl.uniprot.org/uniprot/#_E2GIM5-mappedCitation-34315815 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34315815 |
| http://purl.uniprot.org/uniprot/#_E2GIM6-mappedCitation-34315815 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34315815 |
| http://purl.uniprot.org/uniprot/#_E2GIM7-mappedCitation-34315815 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34315815 |
| http://purl.uniprot.org/uniprot/#_E2GIM8-mappedCitation-34315815 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34315815 |
| http://purl.uniprot.org/uniprot/#_E2GIM9-mappedCitation-34315815 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34315815 |
| http://purl.uniprot.org/uniprot/#_A0A7R8GV38-mappedCitation-34315815 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34315815 |
| http://purl.uniprot.org/uniprot/#_B5BUQ5-mappedCitation-34315815 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34315815 |
| http://purl.uniprot.org/uniprot/#_P39019-mappedCitation-34315815 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34315815 |
| http://purl.uniprot.org/uniprot/#_P42677-mappedCitation-34315815 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34315815 |
| http://purl.uniprot.org/uniprot/#_P62701-mappedCitation-34315815 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34315815 |
| http://purl.uniprot.org/uniprot/#_P62753-mappedCitation-34315815 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34315815 |