| http://purl.uniprot.org/citations/34315863 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34315863 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34315863 | http://www.w3.org/2000/01/rdf-schema#comment | "How the human cytomegalovirus (HCMV) genome-the largest among human herpesviruses-is packaged, retained, and ejected remains unclear. We present the in situ structures of the symmetry-mismatched portal and the capsid vertex-specific components (CVSCs) of HCMV. The 5-fold symmetric 10-helix anchor-uncommon among known portals-contacts the portal-encircling DNA, which is presumed to squeeze the portal as the genome packaging proceeds. We surmise that the 10-helix anchor dampens this action to delay the portal reaching a "head-full" packaging state, thus facilitating the large genome to be packaged. The 6-fold symmetric turret, latched via a coiled coil to a helix from a major capsid protein, supports the portal to retain the packaged genome. CVSCs at the penton vertices-presumed to increase inner capsid pressure-display a low stoichiometry, which would aid genome retention. We also demonstrate that the portal and capsid undergo conformational changes to facilitate genome ejection after viral cell entry."xsd:string |
| http://purl.uniprot.org/citations/34315863 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-021-24820-3"xsd:string |
| http://purl.uniprot.org/citations/34315863 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-021-24820-3"xsd:string |
| http://purl.uniprot.org/citations/34315863 | http://purl.uniprot.org/core/author | "Dong L."xsd:string |
| http://purl.uniprot.org/citations/34315863 | http://purl.uniprot.org/core/author | "Dong L."xsd:string |
| http://purl.uniprot.org/citations/34315863 | http://purl.uniprot.org/core/author | "Li Z."xsd:string |
| http://purl.uniprot.org/citations/34315863 | http://purl.uniprot.org/core/author | "Li Z."xsd:string |
| http://purl.uniprot.org/citations/34315863 | http://purl.uniprot.org/core/author | "Yu X."xsd:string |
| http://purl.uniprot.org/citations/34315863 | http://purl.uniprot.org/core/author | "Yu X."xsd:string |
| http://purl.uniprot.org/citations/34315863 | http://purl.uniprot.org/core/author | "Pang J."xsd:string |
| http://purl.uniprot.org/citations/34315863 | http://purl.uniprot.org/core/author | "Pang J."xsd:string |
| http://purl.uniprot.org/citations/34315863 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34315863 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34315863 | http://purl.uniprot.org/core/name | "Nat. Commun."xsd:string |
| http://purl.uniprot.org/citations/34315863 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/34315863 | http://purl.uniprot.org/core/pages | "4538"xsd:string |
| http://purl.uniprot.org/citations/34315863 | http://purl.uniprot.org/core/pages | "4538"xsd:string |
| http://purl.uniprot.org/citations/34315863 | http://purl.uniprot.org/core/title | "Structural basis for genome packaging, retention, and ejection in human cytomegalovirus."xsd:string |
| http://purl.uniprot.org/citations/34315863 | http://purl.uniprot.org/core/title | "Structural basis for genome packaging, retention, and ejection in human cytomegalovirus."xsd:string |
| http://purl.uniprot.org/citations/34315863 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/34315863 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/34315863 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34315863 |
| http://purl.uniprot.org/citations/34315863 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34315863 |