| http://purl.uniprot.org/citations/34321507 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34321507 | http://www.w3.org/2000/01/rdf-schema#comment | "Staphylococcus aureus virulence has been associated with the production of phenol-soluble modulins (PSMs). These PSMs have distinct virulence functions and are known to activate, attract and lyse neutrophils. These PSM-associated biological functions are inhibited by lipoproteins in vitro. We set out to address whether lipoproteins neutralize staphylococcal PSM-associated virulence in experimental animal models. Serum from both LCAT an ABCA1 knockout mice strains which are characterised by near absence of high-density lipoprotein (HDL) levels, was shown to fail to protect against PSM-induced neutrophil activation and lysis in vitro. Importantly, PSM-induced peritonitis in LCAT-/- mice resulted in increased lysis of resident peritoneal macrophages and enhanced neutrophil recruitment into the peritoneal cavity. Notably, LCAT-/- mice were more likely to succumb to staphylococcal bloodstream infections in a PSM-dependent manner. Plasma from homozygous carriers of ABCA1 variants characterized by very low HDL-cholesterol levels, was found to be less protective against PSM-mediated biological functions compared to healthy humans. Therefore, we conclude that lipoproteins present in blood can protect against staphylococcal PSMs, the key virulence factor of community-associated methicillin resistant S. aureus."xsd:string |
| http://purl.uniprot.org/citations/34321507 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-021-94651-1"xsd:string |
| http://purl.uniprot.org/citations/34321507 | http://purl.uniprot.org/core/author | "Otto M."xsd:string |
| http://purl.uniprot.org/citations/34321507 | http://purl.uniprot.org/core/author | "Hovingh G.K."xsd:string |
| http://purl.uniprot.org/citations/34321507 | http://purl.uniprot.org/core/author | "de Haas C.J.C."xsd:string |
| http://purl.uniprot.org/citations/34321507 | http://purl.uniprot.org/core/author | "Hoekstra M."xsd:string |
| http://purl.uniprot.org/citations/34321507 | http://purl.uniprot.org/core/author | "van Eck M."xsd:string |
| http://purl.uniprot.org/citations/34321507 | http://purl.uniprot.org/core/author | "Hildebrand R.B."xsd:string |
| http://purl.uniprot.org/citations/34321507 | http://purl.uniprot.org/core/author | "Wahlen S."xsd:string |
| http://purl.uniprot.org/citations/34321507 | http://purl.uniprot.org/core/author | "Surewaard B.G.J."xsd:string |
| http://purl.uniprot.org/citations/34321507 | http://purl.uniprot.org/core/author | "Korporaal S.J.A."xsd:string |
| http://purl.uniprot.org/citations/34321507 | http://purl.uniprot.org/core/author | "Kratofil R.M."xsd:string |
| http://purl.uniprot.org/citations/34321507 | http://purl.uniprot.org/core/author | "Hommes J.W."xsd:string |
| http://purl.uniprot.org/citations/34321507 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34321507 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/34321507 | http://purl.uniprot.org/core/pages | "15357"xsd:string |
| http://purl.uniprot.org/citations/34321507 | http://purl.uniprot.org/core/title | "High density lipoproteins mediate in vivo protection against staphylococcal phenol-soluble modulins."xsd:string |
| http://purl.uniprot.org/citations/34321507 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/34321507 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34321507 |
| http://purl.uniprot.org/citations/34321507 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34321507 |
| http://purl.uniprot.org/uniprot/#_P41233-mappedCitation-34321507 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34321507 |
| http://purl.uniprot.org/uniprot/#_Q8BPY1-mappedCitation-34321507 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34321507 |
| http://purl.uniprot.org/uniprot/P41233 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/34321507 |
| http://purl.uniprot.org/uniprot/Q8BPY1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/34321507 |