| http://purl.uniprot.org/citations/34349099 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34349099 | http://www.w3.org/2000/01/rdf-schema#comment | "Cancer is one of the most fatal diseases that threaten human health, whereas more than 90% mortality of cancer patients is caused by tumor metastasis, rather than the growth of primary tumors. Thus, how to effectively control or even reverse the migration of tumor cells is of great significance for cancer therapy. CtBP, a transcriptional cofactor displaying high expression in a variety of human cancers, has become one of the main targets for cancer prediction, diagnosis, and treatment. The roles of CtBP in promoting tumorigenesis have been well studied in vitro, mostly based on gain-of-function, while its physiological functions in tumor invasion and the underlying mechanism remain largely elusive. Snail (Sna) is a well-known transcription factor involved in epithelial-to-mesenchymal transition (EMT) and tumor invasion, yet the mechanism that regulates Sna activity has not been fully understood. Using Drosophila as a model organism, we found that depletion of CtBP or snail (sna) suppressed RasV12/lgl-/--triggered tumor growth and invasion, and disrupted cell polarity-induced invasive cell migration. In addition, loss of CtBP inhibits RasV12/Sna-induced tumor invasion and Sna-mediated invasive cell migration. Furthermore, both CtBP and Sna are physiologically required for developmental cell migration during thorax closure. Finally, Sna activates the JNK signaling and promotes JNK-dependent cell invasion. Given that CtBP physically interacts with Sna, our data suggest that CtBP and Sna may form a transcriptional complex that regulates JNK-dependent tumor invasion and cell migration in vivo."xsd:string |
| http://purl.uniprot.org/citations/34349099 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41420-021-00516-x"xsd:string |
| http://purl.uniprot.org/citations/34349099 | http://purl.uniprot.org/core/author | "Chang H."xsd:string |
| http://purl.uniprot.org/citations/34349099 | http://purl.uniprot.org/core/author | "Huang Y."xsd:string |
| http://purl.uniprot.org/citations/34349099 | http://purl.uniprot.org/core/author | "Li Z."xsd:string |
| http://purl.uniprot.org/citations/34349099 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/34349099 | http://purl.uniprot.org/core/author | "Jiang C."xsd:string |
| http://purl.uniprot.org/citations/34349099 | http://purl.uniprot.org/core/author | "Xu Q."xsd:string |
| http://purl.uniprot.org/citations/34349099 | http://purl.uniprot.org/core/author | "Zhao M."xsd:string |
| http://purl.uniprot.org/citations/34349099 | http://purl.uniprot.org/core/author | "Wu C."xsd:string |
| http://purl.uniprot.org/citations/34349099 | http://purl.uniprot.org/core/author | "Ding X."xsd:string |
| http://purl.uniprot.org/citations/34349099 | http://purl.uniprot.org/core/author | "Lin G."xsd:string |
| http://purl.uniprot.org/citations/34349099 | http://purl.uniprot.org/core/author | "Xue L."xsd:string |
| http://purl.uniprot.org/citations/34349099 | http://purl.uniprot.org/core/author | "Zou R."xsd:string |
| http://purl.uniprot.org/citations/34349099 | http://purl.uniprot.org/core/author | "La X."xsd:string |
| http://purl.uniprot.org/citations/34349099 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34349099 | http://purl.uniprot.org/core/name | "Cell Death Discov"xsd:string |
| http://purl.uniprot.org/citations/34349099 | http://purl.uniprot.org/core/pages | "202"xsd:string |
| http://purl.uniprot.org/citations/34349099 | http://purl.uniprot.org/core/title | "CtBP modulates Snail-mediated tumor invasion in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/34349099 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/34349099 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34349099 |
| http://purl.uniprot.org/citations/34349099 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34349099 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KFT4-mappedCitation-34349099 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34349099 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KFX5-mappedCitation-34349099 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34349099 |