| http://purl.uniprot.org/citations/34351428 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34351428 | http://www.w3.org/2000/01/rdf-schema#comment | "Neocortical progenitor cells generate subtypes of excitatory projection neurons in sequential order followed by the generation of astrocytes. The transcription factor zinc finger and BTB domain-containing protein 20 (ZBTB20) has been implicated in regulation of cell specification during neocortical development. Here, we show that ZBTB20 instructs the generation of a subset of callosal projections neurons in cortical layers II/III in mouse. Conditional deletion of Zbtb20 in cortical progenitors, and to a lesser degree in differentiating neurons, leads to an increase in the number of layer IV neurons at the expense of layer II/III neurons. Astrogliogenesis is also affected in the mutants with an increase in the number of a specific subset of astrocytes expressing GFAP. Astrogliogenesis is more severely disrupted by a ZBTB20 protein containing dominant mutations linked to Primrose syndrome, suggesting that ZBTB20 acts in concert with other ZBTB proteins that were also affected by the dominant-negative protein to instruct astrogliogenesis. Overall, our data suggest that ZBTB20 acts both in progenitors and in postmitotic cells to regulate cell fate specification in the mammalian neocortex."xsd:string |
| http://purl.uniprot.org/citations/34351428 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.196642"xsd:string |
| http://purl.uniprot.org/citations/34351428 | http://purl.uniprot.org/core/author | "Muller U."xsd:string |
| http://purl.uniprot.org/citations/34351428 | http://purl.uniprot.org/core/author | "Espinosa A."xsd:string |
| http://purl.uniprot.org/citations/34351428 | http://purl.uniprot.org/core/author | "Costa M.R."xsd:string |
| http://purl.uniprot.org/citations/34351428 | http://purl.uniprot.org/core/author | "Gil-Sanz C."xsd:string |
| http://purl.uniprot.org/citations/34351428 | http://purl.uniprot.org/core/author | "Barao S."xsd:string |
| http://purl.uniprot.org/citations/34351428 | http://purl.uniprot.org/core/author | "Mateos-White I."xsd:string |
| http://purl.uniprot.org/citations/34351428 | http://purl.uniprot.org/core/author | "Medeiros de Araujo J.A."xsd:string |
| http://purl.uniprot.org/citations/34351428 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34351428 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/34351428 | http://purl.uniprot.org/core/pages | "dev196642"xsd:string |
| http://purl.uniprot.org/citations/34351428 | http://purl.uniprot.org/core/title | "ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex."xsd:string |
| http://purl.uniprot.org/citations/34351428 | http://purl.uniprot.org/core/volume | "148"xsd:string |
| http://purl.uniprot.org/citations/34351428 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34351428 |
| http://purl.uniprot.org/citations/34351428 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34351428 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YW03-mappedCitation-34351428 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34351428 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWR6-mappedCitation-34351428 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34351428 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWT8-mappedCitation-34351428 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34351428 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YX98-mappedCitation-34351428 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34351428 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YXP2-mappedCitation-34351428 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34351428 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YXT0-mappedCitation-34351428 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34351428 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YY33-mappedCitation-34351428 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34351428 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JH01-mappedCitation-34351428 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34351428 |