| http://purl.uniprot.org/citations/34355142 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34355142 | http://www.w3.org/2000/01/rdf-schema#comment | "Derlin family members (Derlins) are primarily known as components of the endoplasmic reticulum-associated degradation pathway that eliminates misfolded proteins. Here we report a function of Derlins in the brain development. Deletion of Derlin-1 or Derlin-2 in the central nervous system of mice impaired postnatal brain development, particularly of the cerebellum and striatum, and induced motor control deficits. Derlin-1 or Derlin-2 deficiency reduced neurite outgrowth in vitro and in vivo and surprisingly also inhibited sterol regulatory element binding protein 2 (SREBP-2)-mediated brain cholesterol biosynthesis. In addition, reduced neurite outgrowth due to Derlin-1 deficiency was rescued by SREBP-2 pathway activation. Overall, our findings demonstrate that Derlins sustain brain cholesterol biosynthesis, which is essential for appropriate postnatal brain development and function."xsd:string |
| http://purl.uniprot.org/citations/34355142 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.isci.2021.102758"xsd:string |
| http://purl.uniprot.org/citations/34355142 | http://purl.uniprot.org/core/author | "Sugiyama T."xsd:string |
| http://purl.uniprot.org/citations/34355142 | http://purl.uniprot.org/core/author | "Shiomi K."xsd:string |
| http://purl.uniprot.org/citations/34355142 | http://purl.uniprot.org/core/author | "Takeda K."xsd:string |
| http://purl.uniprot.org/citations/34355142 | http://purl.uniprot.org/core/author | "Ploegh H.L."xsd:string |
| http://purl.uniprot.org/citations/34355142 | http://purl.uniprot.org/core/author | "Takao K."xsd:string |
| http://purl.uniprot.org/citations/34355142 | http://purl.uniprot.org/core/author | "Matsushita Y."xsd:string |
| http://purl.uniprot.org/citations/34355142 | http://purl.uniprot.org/core/author | "Kawasaki H."xsd:string |
| http://purl.uniprot.org/citations/34355142 | http://purl.uniprot.org/core/author | "Miyakawa T."xsd:string |
| http://purl.uniprot.org/citations/34355142 | http://purl.uniprot.org/core/author | "Mikoshiba K."xsd:string |
| http://purl.uniprot.org/citations/34355142 | http://purl.uniprot.org/core/author | "Sakai J."xsd:string |
| http://purl.uniprot.org/citations/34355142 | http://purl.uniprot.org/core/author | "Katagiri T."xsd:string |
| http://purl.uniprot.org/citations/34355142 | http://purl.uniprot.org/core/author | "Ichijo H."xsd:string |
| http://purl.uniprot.org/citations/34355142 | http://purl.uniprot.org/core/author | "Kadowaki H."xsd:string |
| http://purl.uniprot.org/citations/34355142 | http://purl.uniprot.org/core/author | "Nishitoh H."xsd:string |
| http://purl.uniprot.org/citations/34355142 | http://purl.uniprot.org/core/author | "Nakazato M."xsd:string |
| http://purl.uniprot.org/citations/34355142 | http://purl.uniprot.org/core/author | "Shinmyo Y."xsd:string |
| http://purl.uniprot.org/citations/34355142 | http://purl.uniprot.org/core/author | "Futatsugi A."xsd:string |
| http://purl.uniprot.org/citations/34355142 | http://purl.uniprot.org/core/author | "Murao N."xsd:string |
| http://purl.uniprot.org/citations/34355142 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34355142 | http://purl.uniprot.org/core/name | "iScience"xsd:string |
| http://purl.uniprot.org/citations/34355142 | http://purl.uniprot.org/core/pages | "102758"xsd:string |
| http://purl.uniprot.org/citations/34355142 | http://purl.uniprot.org/core/title | "ERAD components Derlin-1 and Derlin-2 are essential for postnatal brain development and motor function."xsd:string |