| http://purl.uniprot.org/citations/34356051 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34356051 | http://www.w3.org/2000/01/rdf-schema#comment | "Retinoic acid inducible gene G (RIG-G) is an inducible gene produced during the treatment of acute promyelocytic leukemia with all-trans retinoic acid (ATRA). However, it is unclear the expression level of RIG-G gene in the peripheral blood of healthy subjects and patients with acute promyelocytic leukemia (APL or AML-M3). In the present study, we established the TaqMan-MGB fluorescent probe qPCR (real-time polymerase chain reaction) method for the first time to detect the expression of RIG-G gene in APL. Twenty APL patients were selected, and their RIG-G expression levels were quantified to assess the correlation between the expression of peripheral blood and bone marrow samples. U test was used to analyze the expression level of RIG-G in the peripheral blood of 40 normal specimens and 20 APL patients to observe the prognostic monitoring effect of RIG-G gene in the ATRA treatment process. ROC (receiver operating characteristic curve) was used to analyze and test the diagnostic efficiency of RIG-G gene for APL patients. There is a strong positive correlation between the expression of RIG-G in peripheral blood and bone marrow of APL patients. The expression level of RIG-G in peripheral blood of APL patients is significantly lower than that in healthy controls (p < 0.001). The changes in the expression level of RIG-G in peripheral blood changed indicates the remission and recurrence of APL patients after ATRA treatment, and the ROC curve shows that it has a better diagnostic power for APL. In summary, the TaqMan-MGB real-time PCR method we have established has successfully run. The detection of RIG-G gene expression in peripheral blood can effectively monitor the disease changes of APL patients and avoid harmful bone marrow puncture injury."xsd:string |
| http://purl.uniprot.org/citations/34356051 | http://purl.org/dc/terms/identifier | "doi:10.3390/genes12071035"xsd:string |
| http://purl.uniprot.org/citations/34356051 | http://purl.uniprot.org/core/author | "Li D."xsd:string |
| http://purl.uniprot.org/citations/34356051 | http://purl.uniprot.org/core/author | "Sun Z."xsd:string |
| http://purl.uniprot.org/citations/34356051 | http://purl.uniprot.org/core/author | "Wu J."xsd:string |
| http://purl.uniprot.org/citations/34356051 | http://purl.uniprot.org/core/author | "Tian J."xsd:string |
| http://purl.uniprot.org/citations/34356051 | http://purl.uniprot.org/core/author | "Wang F."xsd:string |
| http://purl.uniprot.org/citations/34356051 | http://purl.uniprot.org/core/author | "Yan J."xsd:string |
| http://purl.uniprot.org/citations/34356051 | http://purl.uniprot.org/core/author | "Pang L."xsd:string |
| http://purl.uniprot.org/citations/34356051 | http://purl.uniprot.org/core/author | "Shang A."xsd:string |
| http://purl.uniprot.org/citations/34356051 | http://purl.uniprot.org/core/author | "Quan W."xsd:string |
| http://purl.uniprot.org/citations/34356051 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34356051 | http://purl.uniprot.org/core/name | "Genes (Basel)"xsd:string |
| http://purl.uniprot.org/citations/34356051 | http://purl.uniprot.org/core/pages | "1035"xsd:string |
| http://purl.uniprot.org/citations/34356051 | http://purl.uniprot.org/core/title | "Retinoic Acid-Induced Gene G(RIG-G) as a Novel Monitoring Biomarker in Leukemia and Its Clinical Applications."xsd:string |
| http://purl.uniprot.org/citations/34356051 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/34356051 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34356051 |
| http://purl.uniprot.org/citations/34356051 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34356051 |
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| http://purl.uniprot.org/uniprot/#_Q5T765-mappedCitation-34356051 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34356051 |
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| http://purl.uniprot.org/uniprot/O14879 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/34356051 |