| http://purl.uniprot.org/citations/34360981 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34360981 | http://www.w3.org/2000/01/rdf-schema#comment | "Granulosa-lutein cells (GLCs) from PCOS women display reduced HIF-1α and EDN2 levels, suggesting their role in PCOS etiology. Here, we investigated the mechanisms involved in aberrant EDN2 expression in PCOS, and its association with HIF-1α. Various HIF-1α-dependent factors were studied in GLCs from PCOS and compared to normally ovulating women. MicroRNA-210 (miR-210), its target genes (SDHD and GPD1L), and HIF-1α-responsive genes (EDN2 and VEGFA) differed in GLCs from PCOS, compared with those of healthy women. Levels of miR-210-designated hypoxiamiR-and EDN2 were reduced in the PCOS GLCs; concomitantly, GPD1L and SDHD levels were elevated. Cultured GLCs retained low EDN2 expression and had low HIF-1α levels, providing evidence for a disrupted hypoxic response in the PCOS GLCs. However, VEGFA expression was elevated in these cells. Next, miR-210 levels were manipulated. miR-210-mimic stimulated EDN2 twice as much as the miR-NC-transfected cells, whereas miR-210-inhibitor diminished EDN2, emphasizing the importance of hypoxiamiR for EDN2 induction. Intriguingly, VEGFA transcripts were reduced by both miR-210-mimic and -inhibitor, demonstrating that EDN2 and VEGFA are distinctly regulated. Disrupted hypoxic response in the GLCs of periovulatory follicles in PCOS women may play a role in ovulation failure, and in the reduced fertility prevalent in this syndrome."xsd:string |
| http://purl.uniprot.org/citations/34360981 | http://purl.org/dc/terms/identifier | "doi:10.3390/ijms22158216"xsd:string |
| http://purl.uniprot.org/citations/34360981 | http://purl.uniprot.org/core/author | "Harlev A."xsd:string |
| http://purl.uniprot.org/citations/34360981 | http://purl.uniprot.org/core/author | "Shrestha K."xsd:string |
| http://purl.uniprot.org/citations/34360981 | http://purl.uniprot.org/core/author | "Eisenberg I."xsd:string |
| http://purl.uniprot.org/citations/34360981 | http://purl.uniprot.org/core/author | "Meidan R."xsd:string |
| http://purl.uniprot.org/citations/34360981 | http://purl.uniprot.org/core/author | "Girsh E."xsd:string |
| http://purl.uniprot.org/citations/34360981 | http://purl.uniprot.org/core/author | "Szymanska M."xsd:string |
| http://purl.uniprot.org/citations/34360981 | http://purl.uniprot.org/core/author | "Imbar T."xsd:string |
| http://purl.uniprot.org/citations/34360981 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34360981 | http://purl.uniprot.org/core/name | "Int J Mol Sci"xsd:string |
| http://purl.uniprot.org/citations/34360981 | http://purl.uniprot.org/core/pages | "8216"xsd:string |
| http://purl.uniprot.org/citations/34360981 | http://purl.uniprot.org/core/title | "Reduced Endothelin-2 and Hypoxic Signaling Pathways in Granulosa-Lutein Cells of PCOS Women."xsd:string |
| http://purl.uniprot.org/citations/34360981 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/34360981 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34360981 |
| http://purl.uniprot.org/citations/34360981 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34360981 |
| http://purl.uniprot.org/uniprot/#_D0VY79-mappedCitation-34360981 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34360981 |
| http://purl.uniprot.org/uniprot/#_B2R617-mappedCitation-34360981 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34360981 |
| http://purl.uniprot.org/uniprot/#_A8MYV6-mappedCitation-34360981 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34360981 |
| http://purl.uniprot.org/uniprot/#_B4E2K5-mappedCitation-34360981 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34360981 |
| http://purl.uniprot.org/uniprot/#_B4E2U7-mappedCitation-34360981 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34360981 |
| http://purl.uniprot.org/uniprot/#_B4DL76-mappedCitation-34360981 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34360981 |
| http://purl.uniprot.org/uniprot/#_B4DS34-mappedCitation-34360981 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34360981 |
| http://purl.uniprot.org/uniprot/#_I7GY10-mappedCitation-34360981 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34360981 |