| http://purl.uniprot.org/citations/34364876 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34364876 | http://www.w3.org/2000/01/rdf-schema#comment | "Previously evidence was presented that the single-nucleotide polymorphism rs1344706 located in an intronic region of the ZNF804A gene is associated with reduced transcript levels in fetal brains. This genetic variation in the gene encoding the zinc-finger protein ZNF804A is associated with schizophrenia (SZ) and bipolar disorder. Currently, the molecular and cellular function of ZNF804A is unclear. Here, we generated a high-confidence protein-protein interaction (PPI) network for ZNF804A using a combination of yeast two-hybrid and bioluminescence-based PPI detection assays, directly linking 15 proteins to the disease-associated target protein. Among the top hits was the signal transducer and activator of transcription 2 (STAT2), an interferon-regulated transcription factor. Detailed mechanistic studies revealed that STAT2 binds to the unstructured N terminus of ZNF804A. This interaction is mediated by multiple short amino acid motifs in ZNF804A but not by the conserved C2H2 zinc-finger domain, which is also located at the N terminus. Interestingly, investigations in HEK293 cells demonstrated that ZNF804A and STAT2 both co-translocate from the cytoplasm into the nucleus upon interferon (IFN) treatment. Furthermore, a concentration-dependent effect of ZNF804A overproduction on STAT2-mediated gene expression was observed using a luciferase reporter, which is under the control of an IFN-stimulated response element (ISRE). Together these results indicate the formation of ZNF804A:STAT2 protein complex and its translocation from the cytoplasm into the nucleus upon IFN stimulation, suggesting that it may function as a signal transducer that activates IFN-mediated gene expression programs."xsd:string |
| http://purl.uniprot.org/citations/34364876 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jmb.2021.167184"xsd:string |
| http://purl.uniprot.org/citations/34364876 | http://purl.uniprot.org/core/author | "Wanker E.E."xsd:string |
| http://purl.uniprot.org/citations/34364876 | http://purl.uniprot.org/core/author | "Rasko T."xsd:string |
| http://purl.uniprot.org/citations/34364876 | http://purl.uniprot.org/core/author | "Klockmeier K."xsd:string |
| http://purl.uniprot.org/citations/34364876 | http://purl.uniprot.org/core/author | "Silva Ramos E."xsd:string |
| http://purl.uniprot.org/citations/34364876 | http://purl.uniprot.org/core/author | "Marti Pastor A."xsd:string |
| http://purl.uniprot.org/citations/34364876 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34364876 | http://purl.uniprot.org/core/name | "J Mol Biol"xsd:string |
| http://purl.uniprot.org/citations/34364876 | http://purl.uniprot.org/core/pages | "167184"xsd:string |
| http://purl.uniprot.org/citations/34364876 | http://purl.uniprot.org/core/title | "Schizophrenia risk candidate protein ZNF804A interacts with STAT2 and influences interferon-mediated gene transcription in mammalian cells."xsd:string |
| http://purl.uniprot.org/citations/34364876 | http://purl.uniprot.org/core/volume | "433"xsd:string |
| http://purl.uniprot.org/citations/34364876 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34364876 |
| http://purl.uniprot.org/citations/34364876 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34364876 |
| http://purl.uniprot.org/uniprot/#_P52630-mappedCitation-34364876 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34364876 |
| http://purl.uniprot.org/uniprot/#_A5PKU0-mappedCitation-34364876 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34364876 |
| http://purl.uniprot.org/uniprot/#_B4DHV2-mappedCitation-34364876 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34364876 |
| http://purl.uniprot.org/uniprot/#_A0JLQ9-mappedCitation-34364876 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34364876 |
| http://purl.uniprot.org/uniprot/#_B4DHE0-mappedCitation-34364876 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34364876 |
| http://purl.uniprot.org/uniprot/#_B4DHI1-mappedCitation-34364876 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34364876 |
| http://purl.uniprot.org/uniprot/#_B4DLC8-mappedCitation-34364876 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34364876 |
| http://purl.uniprot.org/uniprot/#_B9EGN2-mappedCitation-34364876 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34364876 |
| http://purl.uniprot.org/uniprot/#_Q7Z570-mappedCitation-34364876 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34364876 |
| http://purl.uniprot.org/uniprot/#_L8E9U1-mappedCitation-34364876 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34364876 |