| http://purl.uniprot.org/citations/34368651 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34368651 | http://www.w3.org/2000/01/rdf-schema#comment | "Intercellular transmission of the second messenger 2',3'-cGAMP, synthesized by the viral DNA sensor cGAMP synthase (cGAS), is a potent mode of bystander activation during host defense. However, whether this mechanism also contributes to cGAS-dependent autoimmunity remains unknown. Here, using a murine bone marrow transplantation strategy, we demonstrate that, in Trex1 -/- -associated autoimmunity, cGAMP shuttling from radioresistant to immune cells induces NF-κB activation, interferon regulatory factor 3 (IRF3) phosphorylation, and subsequent interferon signaling. cGAMP travel prevented myeloid cell and lymphocyte death, promoting their accumulation in secondary lymphoid tissue. Nonetheless, it did not stimulate B cell differentiation into autoantibody-producing plasmablasts or aberrant T cell priming. Although cGAMP-mediated bystander activation did not induce spontaneous organ disease, it did trigger interface dermatitis after UV light exposure, similar to cutaneous lupus erythematosus. These findings reveal that, in Trex1-deficiency, intercellular cGAMP transfer propagates cGAS signaling and, under conducive conditions, causes tissue inflammation."xsd:string |
| http://purl.uniprot.org/citations/34368651 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.isci.2021.102833"xsd:string |
| http://purl.uniprot.org/citations/34368651 | http://purl.uniprot.org/core/author | "Wagner M."xsd:string |
| http://purl.uniprot.org/citations/34368651 | http://purl.uniprot.org/core/author | "Brossart P."xsd:string |
| http://purl.uniprot.org/citations/34368651 | http://purl.uniprot.org/core/author | "Bartok E."xsd:string |
| http://purl.uniprot.org/citations/34368651 | http://purl.uniprot.org/core/author | "Carell T."xsd:string |
| http://purl.uniprot.org/citations/34368651 | http://purl.uniprot.org/core/author | "Boor P."xsd:string |
| http://purl.uniprot.org/citations/34368651 | http://purl.uniprot.org/core/author | "Wenzel J."xsd:string |
| http://purl.uniprot.org/citations/34368651 | http://purl.uniprot.org/core/author | "Cieslak K."xsd:string |
| http://purl.uniprot.org/citations/34368651 | http://purl.uniprot.org/core/author | "Landsberg J."xsd:string |
| http://purl.uniprot.org/citations/34368651 | http://purl.uniprot.org/core/author | "Teichmann L.L."xsd:string |
| http://purl.uniprot.org/citations/34368651 | http://purl.uniprot.org/core/author | "Aymans P."xsd:string |
| http://purl.uniprot.org/citations/34368651 | http://purl.uniprot.org/core/author | "Graef C.M."xsd:string |
| http://purl.uniprot.org/citations/34368651 | http://purl.uniprot.org/core/author | "Jutte B.B."xsd:string |
| http://purl.uniprot.org/citations/34368651 | http://purl.uniprot.org/core/author | "Koerber R.M."xsd:string |
| http://purl.uniprot.org/citations/34368651 | http://purl.uniprot.org/core/author | "Krollmann C."xsd:string |
| http://purl.uniprot.org/citations/34368651 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34368651 | http://purl.uniprot.org/core/name | "iScience"xsd:string |
| http://purl.uniprot.org/citations/34368651 | http://purl.uniprot.org/core/pages | "102833"xsd:string |
| http://purl.uniprot.org/citations/34368651 | http://purl.uniprot.org/core/title | "Intercellular cGAMP transmission induces innate immune activation and tissue inflammation in Trex1 deficiency."xsd:string |
| http://purl.uniprot.org/citations/34368651 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/34368651 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34368651 |
| http://purl.uniprot.org/citations/34368651 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34368651 |
| http://purl.uniprot.org/uniprot/#_A0A125R9I3-mappedCitation-34368651 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34368651 |