| http://purl.uniprot.org/citations/34374750 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34374750 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34374750 | http://www.w3.org/2000/01/rdf-schema#comment | "Intestinal myeloid cells play a critical role in balancing intestinal homeostasis and inflammation. Here, we report that expression of the autophagy-related 5 [Atg5] protein in myeloid cells prevents dysbiosis and excessive intestinal inflammation by limiting IL-12 production. Mice with a selective genetic deletion of Atg5 in myeloid cells [Atg5ΔMye] showed signs of dysbiosis preceding colitis, and exhibited severe intestinal inflammation upon colitis induction that was characterised by increased IFNγ production. The exacerbated colitis was linked to excess IL-12 secretion from Atg5-deficient myeloid cells and gut dysbiosis. Restoration of the intestinal microbiota or genetic deletion of IL-12 in Atg5ΔMye mice attenuated the intestinal inflammation in Atg5ΔMye mice. Additionally, Atg5 functions to limit IL-12 secretion through modulation of late endosome [LE] acidity. Last, the autophagy cargo receptor NBR1, which accumulates in Atg5-deficient cells, played a role by delivering IL-12 to LE. In summary, Atg5 expression in intestinal myeloid cells acts as an anti-inflammatory brake to regulate IL-12, thus preventing dysbiosis and uncontrolled IFNγ-driven intestinal inflammation."xsd:string |
| http://purl.uniprot.org/citations/34374750 | http://purl.org/dc/terms/identifier | "doi:10.1093/ecco-jcc/jjab144"xsd:string |
| http://purl.uniprot.org/citations/34374750 | http://purl.org/dc/terms/identifier | "doi:10.1093/ecco-jcc/jjab144"xsd:string |
| http://purl.uniprot.org/citations/34374750 | http://purl.uniprot.org/core/author | "Guo Y."xsd:string |
| http://purl.uniprot.org/citations/34374750 | http://purl.uniprot.org/core/author | "Guo Y."xsd:string |
| http://purl.uniprot.org/citations/34374750 | http://purl.uniprot.org/core/author | "Deretic V."xsd:string |
| http://purl.uniprot.org/citations/34374750 | http://purl.uniprot.org/core/author | "Deretic V."xsd:string |
| http://purl.uniprot.org/citations/34374750 | http://purl.uniprot.org/core/author | "Castillo E.F."xsd:string |
| http://purl.uniprot.org/citations/34374750 | http://purl.uniprot.org/core/author | "Castillo E.F."xsd:string |
| http://purl.uniprot.org/citations/34374750 | http://purl.uniprot.org/core/author | "Dinwiddie D.L."xsd:string |
| http://purl.uniprot.org/citations/34374750 | http://purl.uniprot.org/core/author | "Dinwiddie D.L."xsd:string |
| http://purl.uniprot.org/citations/34374750 | http://purl.uniprot.org/core/author | "Bradfute S.B."xsd:string |
| http://purl.uniprot.org/citations/34374750 | http://purl.uniprot.org/core/author | "Bradfute S.B."xsd:string |
| http://purl.uniprot.org/citations/34374750 | http://purl.uniprot.org/core/author | "In J.G."xsd:string |
| http://purl.uniprot.org/citations/34374750 | http://purl.uniprot.org/core/author | "In J.G."xsd:string |
| http://purl.uniprot.org/citations/34374750 | http://purl.uniprot.org/core/author | "Byrum J.R."xsd:string |
| http://purl.uniprot.org/citations/34374750 | http://purl.uniprot.org/core/author | "Byrum J.R."xsd:string |
| http://purl.uniprot.org/citations/34374750 | http://purl.uniprot.org/core/author | "Goodfellow S.M."xsd:string |
| http://purl.uniprot.org/citations/34374750 | http://purl.uniprot.org/core/author | "Goodfellow S.M."xsd:string |
| http://purl.uniprot.org/citations/34374750 | http://purl.uniprot.org/core/author | "Gullapalli R.R."xsd:string |
| http://purl.uniprot.org/citations/34374750 | http://purl.uniprot.org/core/author | "Gullapalli R.R."xsd:string |
| http://purl.uniprot.org/citations/34374750 | http://purl.uniprot.org/core/author | "Jimenez Hernandez A."xsd:string |
| http://purl.uniprot.org/citations/34374750 | http://purl.uniprot.org/core/author | "Jimenez Hernandez A."xsd:string |