| http://purl.uniprot.org/citations/34375765 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34375765 | http://www.w3.org/2000/01/rdf-schema#comment | "As a common treatment of human glioma, ionizing radiation (IR) was reported to result in cell cycle arrest. However, the mechanisms underlying IR-induced abnormal cell cycle remain largely unclear. Here we found that IR caused an elevated expression of B-Myb and cell cycle-related proteins, as well as G2/M phase arrest in U251 cells instead of U87 cells. However, the knockdown of B-Myb by small interfering RNAs ameliorated the increasing of cell cycle-related proteins and G2/M phase arrest induced by IR. Further analysis demonstrated that decreased-B-Myb enhanced the sensitivity of U251 cells to IR. Moreover, the establishment of H1299 cell line proved that B-Myb expression was associated with the status of p53. Immunoprecipitation (IP) and chromatin immunoprecipitation (CHIP) assay results indicated that mutant p53 and SP1 regulated the expression of B-Myb via different mechanisms. This study not only elucidated the role of B-Myb in IR-induced cell cycle alternation, but also provided insight into mechanism of B-Myb expression."xsd:string |
| http://purl.uniprot.org/citations/34375765 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2021.08.014"xsd:string |
| http://purl.uniprot.org/citations/34375765 | http://purl.uniprot.org/core/author | "Cao H."xsd:string |
| http://purl.uniprot.org/citations/34375765 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/34375765 | http://purl.uniprot.org/core/author | "Lin F."xsd:string |
| http://purl.uniprot.org/citations/34375765 | http://purl.uniprot.org/core/author | "Zhu Y."xsd:string |
| http://purl.uniprot.org/citations/34375765 | http://purl.uniprot.org/core/author | "Zhao Y."xsd:string |
| http://purl.uniprot.org/citations/34375765 | http://purl.uniprot.org/core/author | "Shen X."xsd:string |
| http://purl.uniprot.org/citations/34375765 | http://purl.uniprot.org/core/author | "Liang Z."xsd:string |
| http://purl.uniprot.org/citations/34375765 | http://purl.uniprot.org/core/author | "Zuo W."xsd:string |
| http://purl.uniprot.org/citations/34375765 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34375765 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/34375765 | http://purl.uniprot.org/core/pages | "19-26"xsd:string |
| http://purl.uniprot.org/citations/34375765 | http://purl.uniprot.org/core/title | "B-Myb participated in ionizing radiation-induced apoptosis and cell cycle arrest in human glioma cells."xsd:string |
| http://purl.uniprot.org/citations/34375765 | http://purl.uniprot.org/core/volume | "573"xsd:string |
| http://purl.uniprot.org/citations/34375765 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34375765 |
| http://purl.uniprot.org/citations/34375765 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34375765 |
| http://purl.uniprot.org/uniprot/#_P10244-mappedCitation-34375765 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34375765 |
| http://purl.uniprot.org/uniprot/P10244 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/34375765 |