| http://purl.uniprot.org/citations/34380015 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34380015 | http://www.w3.org/2000/01/rdf-schema#comment | "The Hsp90 chaperone promotes folding and activation of hundreds of client proteins in the cell through an ATP-dependent conformational cycle guided by distinct cochaperone regulators. The FKBP51 immunophilin binds Hsp90 with its tetratricopeptide repeat (TPR) domain and catalyzes peptidyl-prolyl isomerase (PPIase) activity during folding of kinases, nuclear receptors, and tau. Here we determined the cryoelectron microscopy (cryo-EM) structure of the human Hsp90:FKBP51:p23 complex to 3.3 Å, which, together with mutagenesis and crosslinking analyses, reveals the basis for cochaperone binding to Hsp90 during client maturation. A helix extension in the TPR functions as a key recognition element, interacting across the Hsp90 C-terminal dimer interface presented in the closed, ATP conformation. The PPIase domain is positioned along the middle domain, adjacent to Hsp90 client binding sites, whereas a single p23 makes stabilizing interactions with the N-terminal dimer. With this architecture, FKBP51 is positioned to act on specific client residues presented during Hsp90-catalyzed remodeling."xsd:string |
| http://purl.uniprot.org/citations/34380015 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2021.07.023"xsd:string |
| http://purl.uniprot.org/citations/34380015 | http://purl.uniprot.org/core/author | "Lee K."xsd:string |
| http://purl.uniprot.org/citations/34380015 | http://purl.uniprot.org/core/author | "Southworth D.R."xsd:string |
| http://purl.uniprot.org/citations/34380015 | http://purl.uniprot.org/core/author | "Thwin A.C."xsd:string |
| http://purl.uniprot.org/citations/34380015 | http://purl.uniprot.org/core/author | "Tse E."xsd:string |
| http://purl.uniprot.org/citations/34380015 | http://purl.uniprot.org/core/author | "Gestwicki J.E."xsd:string |
| http://purl.uniprot.org/citations/34380015 | http://purl.uniprot.org/core/author | "Gates S.N."xsd:string |
| http://purl.uniprot.org/citations/34380015 | http://purl.uniprot.org/core/author | "Nadel C.M."xsd:string |
| http://purl.uniprot.org/citations/34380015 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34380015 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/34380015 | http://purl.uniprot.org/core/pages | "3496-3508.e5"xsd:string |
| http://purl.uniprot.org/citations/34380015 | http://purl.uniprot.org/core/title | "The structure of an Hsp90-immunophilin complex reveals cochaperone recognition of the client maturation state."xsd:string |
| http://purl.uniprot.org/citations/34380015 | http://purl.uniprot.org/core/volume | "81"xsd:string |
| http://purl.uniprot.org/citations/34380015 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34380015 |
| http://purl.uniprot.org/citations/34380015 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34380015 |
| http://purl.uniprot.org/uniprot/#_A0A0P1J1R0-mappedCitation-34380015 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34380015 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J2C3-mappedCitation-34380015 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34380015 |
| http://purl.uniprot.org/uniprot/#_B4DKJ4-mappedCitation-34380015 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34380015 |
| http://purl.uniprot.org/uniprot/#_B4DTA5-mappedCitation-34380015 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34380015 |
| http://purl.uniprot.org/uniprot/#_B7Z8G2-mappedCitation-34380015 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34380015 |
| http://purl.uniprot.org/uniprot/#_B4DLD6-mappedCitation-34380015 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34380015 |
| http://purl.uniprot.org/uniprot/#_B7Z7Z8-mappedCitation-34380015 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34380015 |
| http://purl.uniprot.org/uniprot/#_Q53GX4-mappedCitation-34380015 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34380015 |