| http://purl.uniprot.org/citations/34380029 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34380029 | http://www.w3.org/2000/01/rdf-schema#comment | "Loss of function of adenosine deaminase acting on double-stranded RNA (dsRNA)-1 (ADAR1) causes the severe autoinflammatory disease Aicardi-Goutières syndrome (AGS). ADAR1 converts adenosines into inosines within dsRNA. This process called A-to-I editing masks self-dsRNA from detection by the antiviral dsRNA sensor MDA5. ADAR1 binds to dsRNA in both the canonical A-form and the poorly defined Z conformation (Z-RNA). Mutations in the Z-RNA-binding Zα domain of ADAR1 are common in patients with AGS. How loss of ADAR1/Z-RNA interaction contributes to disease development is unknown. We demonstrate that abrogated binding of ADAR1 to Z-RNA leads to reduced A-to-I editing of dsRNA structures formed by base pairing of inversely oriented short interspersed nuclear elements. Preventing ADAR1 binding to Z-RNA triggers an MDA5/MAVS-mediated type I interferon response and leads to the development of lethal autoinflammation in mice. This shows that the interaction between ADAR1 and Z-RNA restricts sensing of self-dsRNA and prevents AGS development."xsd:string |
| http://purl.uniprot.org/citations/34380029 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2021.109500"xsd:string |
| http://purl.uniprot.org/citations/34380029 | http://purl.uniprot.org/core/author | "Vandenabeele P."xsd:string |
| http://purl.uniprot.org/citations/34380029 | http://purl.uniprot.org/core/author | "Maelfait J."xsd:string |
| http://purl.uniprot.org/citations/34380029 | http://purl.uniprot.org/core/author | "Staes K."xsd:string |
| http://purl.uniprot.org/citations/34380029 | http://purl.uniprot.org/core/author | "Van Nieuwerburgh F."xsd:string |
| http://purl.uniprot.org/citations/34380029 | http://purl.uniprot.org/core/author | "Lambrecht B.N."xsd:string |
| http://purl.uniprot.org/citations/34380029 | http://purl.uniprot.org/core/author | "de Reuver R."xsd:string |
| http://purl.uniprot.org/citations/34380029 | http://purl.uniprot.org/core/author | "Dierick E."xsd:string |
| http://purl.uniprot.org/citations/34380029 | http://purl.uniprot.org/core/author | "Botzki A."xsd:string |
| http://purl.uniprot.org/citations/34380029 | http://purl.uniprot.org/core/author | "De Meester E."xsd:string |
| http://purl.uniprot.org/citations/34380029 | http://purl.uniprot.org/core/author | "Wiernicki B."xsd:string |
| http://purl.uniprot.org/citations/34380029 | http://purl.uniprot.org/core/author | "Muyldermans T."xsd:string |
| http://purl.uniprot.org/citations/34380029 | http://purl.uniprot.org/core/author | "Seys L."xsd:string |
| http://purl.uniprot.org/citations/34380029 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34380029 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/34380029 | http://purl.uniprot.org/core/pages | "109500"xsd:string |
| http://purl.uniprot.org/citations/34380029 | http://purl.uniprot.org/core/title | "ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation."xsd:string |
| http://purl.uniprot.org/citations/34380029 | http://purl.uniprot.org/core/volume | "36"xsd:string |
| http://purl.uniprot.org/citations/34380029 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34380029 |
| http://purl.uniprot.org/citations/34380029 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34380029 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YXF5-mappedCitation-34380029 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34380029 |
| http://purl.uniprot.org/uniprot/#_A0A024DAK3-mappedCitation-34380029 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34380029 |
| http://purl.uniprot.org/uniprot/#_D3YYR0-mappedCitation-34380029 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34380029 |