| http://purl.uniprot.org/citations/34385 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34385 | http://www.w3.org/2000/01/rdf-schema#comment | "1. Data are provided that indicate that the rat brain acetoacetyl-CoA deacylase is almost exclusively mitochondrial. Developmental studies show that this enzyme more than doubles its activity during suckling (0--21 days) and then maintains this activity in adults (approx. 1.1 units/g wet wt.). 2. Kinetic studies (on the acetoacetyl-CoA deacylase) in a purified brain mitochondrial preparation give a Vmax. of 47 nmol/min per mg of protein, and a Km for acetoacetyl-CoA of 5.2 micron and are compatible with substrate inhibition by acetoacetyl-CoA above concentrations of 47 micron. 3. The total brain 3-hydroxy-3-methyl-glutaryl-CoA synthase remains constant in the developing and adult rat brain (approx. 1.2 units/g wet wt.). This enzyme is located in both the mitochondrial and cytosolic fractions. During suckling (0--21 days) the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase represents approx. one-third of the total, but this increases markedly to about 60% of the total in the adult. The cytosolic enzyme correspondingly falls to approx. 40% of the total. 4. The role of the acetoacetyl-CoA deacylase in providing cytosolic acetoacetate for biosynthetic activities in the developing brain is discussed."xsd:string |
| http://purl.uniprot.org/citations/34385 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj1760951"xsd:string |
| http://purl.uniprot.org/citations/34385 | http://purl.uniprot.org/core/author | "Clark J.B."xsd:string |
| http://purl.uniprot.org/citations/34385 | http://purl.uniprot.org/core/author | "Patel T.B."xsd:string |
| http://purl.uniprot.org/citations/34385 | http://purl.uniprot.org/core/date | "1978"xsd:gYear |
| http://purl.uniprot.org/citations/34385 | http://purl.uniprot.org/core/name | "Biochem J"xsd:string |
| http://purl.uniprot.org/citations/34385 | http://purl.uniprot.org/core/pages | "951-958"xsd:string |
| http://purl.uniprot.org/citations/34385 | http://purl.uniprot.org/core/title | "Acetoacetate metabolism in rat brain. Development of acetoacetyl-coenzyme A deacylase and 3-hydroxy-3-methylglutaryl-coenzyme A synthase."xsd:string |
| http://purl.uniprot.org/citations/34385 | http://purl.uniprot.org/core/volume | "176"xsd:string |
| http://purl.uniprot.org/citations/34385 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34385 |
| http://purl.uniprot.org/citations/34385 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34385 |
| http://purl.uniprot.org/uniprot/#_P22791-mappedCitation-34385 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34385 |
| http://purl.uniprot.org/uniprot/P22791 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/34385 |