| http://purl.uniprot.org/citations/34385184 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34385184 | http://www.w3.org/2000/01/rdf-schema#comment | "Chromosomal translocations generate oncogenic fusion proteins in approximately one-third of sarcomas, but how these proteins promote tumorigenesis is not well understood. Interestingly, some translocation-driven cancers exhibit dramatic clinical responses to therapy, such as radiotherapy, although the precise mechanism has not been elucidated. Here we reveal a molecular mechanism by which the fusion oncoprotein FUS-CHOP promotes tumor maintenance that also explains the remarkable sensitivity of myxoid liposarcomas to radiation therapy. FUS-CHOP interacted with chromatin remodeling complexes to regulate sarcoma cell proliferation. One of these chromatin remodelers, SNF2H, colocalized with FUS-CHOP genome-wide at active enhancers. Following ionizing radiation, DNA damage response kinases phosphorylated the prion-like domain of FUS-CHOP to impede these protein-protein interactions, which are required for transformation. Therefore, the DNA damage response after irradiation disrupted oncogenic targeting of chromatin remodelers required for FUS-CHOP-driven sarcomagenesis. This mechanism of disruption links phosphorylation of the prion-like domain of an oncogenic fusion protein to DNA damage after ionizing radiation and reveals that a dependence on oncogenic chromatin remodeling underlies sensitivity to radiation therapy in myxoid liposarcoma. SIGNIFICANCE: Prion-like domains, which are frequently translocated in cancers as oncogenic fusion proteins that drive global epigenetic changes, confer sensitivity to radiation via disruption of oncogenic interactions."xsd:string |
| http://purl.uniprot.org/citations/34385184 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-20-1497"xsd:string |
| http://purl.uniprot.org/citations/34385184 | http://purl.uniprot.org/core/author | "Chen M."xsd:string |
| http://purl.uniprot.org/citations/34385184 | http://purl.uniprot.org/core/author | "Davis I.J."xsd:string |
| http://purl.uniprot.org/citations/34385184 | http://purl.uniprot.org/core/author | "Xu E."xsd:string |
| http://purl.uniprot.org/citations/34385184 | http://purl.uniprot.org/core/author | "Kirsch D.G."xsd:string |
| http://purl.uniprot.org/citations/34385184 | http://purl.uniprot.org/core/author | "Daniel A.R."xsd:string |
| http://purl.uniprot.org/citations/34385184 | http://purl.uniprot.org/core/author | "Foster J.P."xsd:string |
| http://purl.uniprot.org/citations/34385184 | http://purl.uniprot.org/core/author | "Leisenring N.H."xsd:string |
| http://purl.uniprot.org/citations/34385184 | http://purl.uniprot.org/core/author | "Floyd W."xsd:string |
| http://purl.uniprot.org/citations/34385184 | http://purl.uniprot.org/core/author | "Lock I.C."xsd:string |
| http://purl.uniprot.org/citations/34385184 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34385184 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/34385184 | http://purl.uniprot.org/core/pages | "4939-4948"xsd:string |
| http://purl.uniprot.org/citations/34385184 | http://purl.uniprot.org/core/title | "Radiation-Induced Phosphorylation of a Prion-Like Domain Regulates Transformation by FUS-CHOP."xsd:string |
| http://purl.uniprot.org/citations/34385184 | http://purl.uniprot.org/core/volume | "81"xsd:string |
| http://purl.uniprot.org/citations/34385184 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34385184 |
| http://purl.uniprot.org/citations/34385184 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34385184 |
| http://purl.uniprot.org/uniprot/#_P35638-mappedCitation-34385184 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34385184 |
| http://purl.uniprot.org/uniprot/#_P0DPQ6-mappedCitation-34385184 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34385184 |
| http://purl.uniprot.org/uniprot/#_Q53YD1-mappedCitation-34385184 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34385184 |
| http://purl.uniprot.org/uniprot/P35638 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/34385184 |
| http://purl.uniprot.org/uniprot/Q53YD1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/34385184 |
| http://purl.uniprot.org/uniprot/P0DPQ6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/34385184 |