| http://purl.uniprot.org/citations/34385690 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34385690 | http://www.w3.org/2000/01/rdf-schema#comment | "The B.1.1.7 variant of SARS-CoV-2 first detected in the UK harbors amino-acid substitutions and deletions in the spike protein that potentially enhance host angiotensin conversion enzyme 2 (ACE2) receptor binding and viral immune evasion. Here we report cryo-EM structures of the spike protein of B.1.1.7 in the apo and ACE2-bound forms. The apo form showed one or two receptor-binding domains (RBDs) in the open conformation, without populating the fully closed state. All three RBDs were engaged in ACE2 binding. The B.1.1.7-specific A570D mutation introduces a molecular switch that could modulate the opening and closing of the RBD. The N501Y mutation introduces a π-π interaction that enhances RBD binding to ACE2 and abolishes binding of a potent neutralizing antibody (nAb). Cryo-EM also revealed how a cocktail of two nAbs simultaneously bind to all three RBDs, and demonstrated the potency of the nAb cocktail to neutralize different SARS-CoV-2 pseudovirus strains, including B.1.1.7."xsd:string |
| http://purl.uniprot.org/citations/34385690 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41594-021-00652-z"xsd:string |
| http://purl.uniprot.org/citations/34385690 | http://purl.uniprot.org/core/author | "Wu H.C."xsd:string |
| http://purl.uniprot.org/citations/34385690 | http://purl.uniprot.org/core/author | "Chang Y.C."xsd:string |
| http://purl.uniprot.org/citations/34385690 | http://purl.uniprot.org/core/author | "Ho M.R."xsd:string |
| http://purl.uniprot.org/citations/34385690 | http://purl.uniprot.org/core/author | "Yang T.J."xsd:string |
| http://purl.uniprot.org/citations/34385690 | http://purl.uniprot.org/core/author | "Chen W.Y."xsd:string |
| http://purl.uniprot.org/citations/34385690 | http://purl.uniprot.org/core/author | "Lin H.T."xsd:string |
| http://purl.uniprot.org/citations/34385690 | http://purl.uniprot.org/core/author | "Liang K.H."xsd:string |
| http://purl.uniprot.org/citations/34385690 | http://purl.uniprot.org/core/author | "Hsu S.D."xsd:string |
| http://purl.uniprot.org/citations/34385690 | http://purl.uniprot.org/core/author | "Yu P.Y."xsd:string |
| http://purl.uniprot.org/citations/34385690 | http://purl.uniprot.org/core/author | "Tso H.C."xsd:string |
| http://purl.uniprot.org/citations/34385690 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34385690 | http://purl.uniprot.org/core/name | "Nat Struct Mol Biol"xsd:string |
| http://purl.uniprot.org/citations/34385690 | http://purl.uniprot.org/core/pages | "731-739"xsd:string |
| http://purl.uniprot.org/citations/34385690 | http://purl.uniprot.org/core/title | "Effect of SARS-CoV-2 B.1.1.7 mutations on spike protein structure and function."xsd:string |
| http://purl.uniprot.org/citations/34385690 | http://purl.uniprot.org/core/volume | "28"xsd:string |
| http://purl.uniprot.org/citations/34385690 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34385690 |
| http://purl.uniprot.org/citations/34385690 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34385690 |
| http://purl.uniprot.org/uniprot/P0DTC2#attribution-653553298726AB2317AF88396E18E8E9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/34385690 |
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| http://purl.uniprot.org/uniprot/#_P0DTC2-mappedCitation-34385690 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34385690 |
| http://purl.uniprot.org/uniprot/#_Q9BYF1-mappedCitation-34385690 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34385690 |
| http://purl.uniprot.org/uniprot/Q9BYF1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/34385690 |