| http://purl.uniprot.org/citations/34389720 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34389720 | http://www.w3.org/2000/01/rdf-schema#comment | "Diabetes results from a decline in functional pancreatic β-cells, but the molecular mechanisms underlying the pathological β-cell failure are poorly understood. Here we report that large-tumor suppressor 2 (LATS2), a core component of the Hippo signaling pathway, is activated under diabetic conditions and induces β-cell apoptosis and impaired function. LATS2 deficiency in β-cells and primary isolated human islets as well as β-cell specific LATS2 ablation in mice improves β-cell viability, insulin secretion and β-cell mass and ameliorates diabetes development. LATS2 activates mechanistic target of rapamycin complex 1 (mTORC1), a physiological suppressor of autophagy, in β-cells and genetic and pharmacological inhibition of mTORC1 counteracts the pro-apoptotic action of activated LATS2. We further show a direct interplay between Hippo and autophagy, in which LATS2 is an autophagy substrate. On the other hand, LATS2 regulates β-cell apoptosis triggered by impaired autophagy suggesting an existence of a stress-sensitive multicomponent cellular loop coordinating β-cell compensation and survival. Our data reveal an important role for LATS2 in pancreatic β-cell turnover and suggest LATS2 as a potential therapeutic target to improve pancreatic β-cell survival and function in diabetes."xsd:string |
| http://purl.uniprot.org/citations/34389720 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-021-25145-x"xsd:string |
| http://purl.uniprot.org/citations/34389720 | http://purl.uniprot.org/core/author | "Pal A."xsd:string |
| http://purl.uniprot.org/citations/34389720 | http://purl.uniprot.org/core/author | "Yuan T."xsd:string |
| http://purl.uniprot.org/citations/34389720 | http://purl.uniprot.org/core/author | "Naik S."xsd:string |
| http://purl.uniprot.org/citations/34389720 | http://purl.uniprot.org/core/author | "Dobrowolski A."xsd:string |
| http://purl.uniprot.org/citations/34389720 | http://purl.uniprot.org/core/author | "Lim D.S."xsd:string |
| http://purl.uniprot.org/citations/34389720 | http://purl.uniprot.org/core/author | "Maedler K."xsd:string |
| http://purl.uniprot.org/citations/34389720 | http://purl.uniprot.org/core/author | "Azizi Z."xsd:string |
| http://purl.uniprot.org/citations/34389720 | http://purl.uniprot.org/core/author | "Ardestani A."xsd:string |
| http://purl.uniprot.org/citations/34389720 | http://purl.uniprot.org/core/author | "Lupse B."xsd:string |
| http://purl.uniprot.org/citations/34389720 | http://purl.uniprot.org/core/author | "Annamalai K."xsd:string |
| http://purl.uniprot.org/citations/34389720 | http://purl.uniprot.org/core/author | "Gorrepati K.D.D."xsd:string |
| http://purl.uniprot.org/citations/34389720 | http://purl.uniprot.org/core/author | "Geravandi S."xsd:string |
| http://purl.uniprot.org/citations/34389720 | http://purl.uniprot.org/core/author | "Ghawali J."xsd:string |
| http://purl.uniprot.org/citations/34389720 | http://purl.uniprot.org/core/author | "Ruhlandt M."xsd:string |
| http://purl.uniprot.org/citations/34389720 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34389720 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/34389720 | http://purl.uniprot.org/core/pages | "4928"xsd:string |
| http://purl.uniprot.org/citations/34389720 | http://purl.uniprot.org/core/title | "The Hippo kinase LATS2 impairs pancreatic beta-cell survival in diabetes through the mTORC1-autophagy axis."xsd:string |
| http://purl.uniprot.org/citations/34389720 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/34389720 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34389720 |
| http://purl.uniprot.org/citations/34389720 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34389720 |
| http://purl.uniprot.org/uniprot/#_D0FZQ3-mappedCitation-34389720 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34389720 |