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| http://purl.uniprot.org/citations/34395437 | http://www.w3.org/2000/01/rdf-schema#comment | "The speckle-type POZ protein (SPOP) functions as a guardian of genome integrity and controls transcriptional regulation by functioning as a substrate adaptor for CUL3/RING-type E3 ubiquitin ligase complexes. SPOP-containing CUL3 complexes target a myriad of DNA-binding proteins involved in DNA repair and gene expression, and as such, are essential modulators of cellular homeostasis. GLI transcription factors are effectors of the Hedgehog (HH) pathway, a key driver of tissue morphogenesis and post-developmental homeostasis that is commonly corrupted in cancer. CUL3-SPOP activity regulates amplitude and duration of HH transcriptional responses by controlling stability of GLI family members. SPOP and GLI co-enrich in phase separated nuclear droplets that are thought to serve as hot spots for CUL3-mediated GLI ubiquitination and degradation. A similar framework exists in Drosophila, in which the Hedgehog-induced MATH (meprin and traf homology) and BTB (bric à brac, tramtrack, broad complex) domain containing protein (HIB) targets the GLI ortholog Cubitus interruptus (Ci) for Cul3-directed proteolysis. Despite this functional conservation, the molecular mechanisms by which HIB and SPOP contribute to Drosophila and vertebrate HH signaling differ. In this mini-review we highlight similarities between the two systems and discuss evolutionary divergence in GLI/Ci targeting that informs our understanding of how the GLI transcriptional code is controlled by SPOP and CUL3 in health and disease."xsd:string |
| http://purl.uniprot.org/citations/34395437 | http://purl.org/dc/terms/identifier | "doi:10.3389/fcell.2021.710295"xsd:string |
| http://purl.uniprot.org/citations/34395437 | http://purl.uniprot.org/core/author | "Ogden S.K."xsd:string |
| http://purl.uniprot.org/citations/34395437 | http://purl.uniprot.org/core/author | "Umberger P.A."xsd:string |
| http://purl.uniprot.org/citations/34395437 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34395437 | http://purl.uniprot.org/core/name | "Front Cell Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/34395437 | http://purl.uniprot.org/core/pages | "710295"xsd:string |
| http://purl.uniprot.org/citations/34395437 | http://purl.uniprot.org/core/title | "SPOP and CUL3 Modulate the Sonic Hedgehog Signal Response Through Controlled Degradation of GLI Family Transcription Factors."xsd:string |
| http://purl.uniprot.org/citations/34395437 | http://purl.uniprot.org/core/volume | "9"xsd:string |
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