| http://purl.uniprot.org/citations/34402812 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34402812 | http://www.w3.org/2000/01/rdf-schema#comment | "Membrane-bound factors expressed by niche stromal cells constitute a unique class of localized cues and regulate the long-term functions of adult stem cells, yet little is known about the underlying mechanisms. Here, we used a supported lipid bilayer (SLB) to recapitulate the membrane-bound interactions between hematopoietic stem cells (HSCs) and niche stromal cells. HSCs cluster membrane-bound stem cell factor (mSCF) at the HSC-SLB interface. They further form a polarized morphology with aggregated mSCF under a large protrusion through a synergy with VCAM-1 on the bilayer, which drastically enhances HSC adhesion. These features are unique to mSCF and HSCs among the factors and hematopoietic populations we examined. The mSCF-VCAM-1 synergy and the polarized HSC morphology require PI3K signaling and cytoskeletal reorganization. The synergy also enhances nuclear retention of FOXO3a, a crucial factor for HSC maintenance, and minimizes its loss induced by soluble SCF. Our work thus reveals a unique role and signaling mechanism of membrane-bound factors in regulating stem cell morphology and function."xsd:string |
| http://purl.uniprot.org/citations/34402812 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.202010118"xsd:string |
| http://purl.uniprot.org/citations/34402812 | http://purl.uniprot.org/core/author | "Hao J."xsd:string |
| http://purl.uniprot.org/citations/34402812 | http://purl.uniprot.org/core/author | "Lu R."xsd:string |
| http://purl.uniprot.org/citations/34402812 | http://purl.uniprot.org/core/author | "Nemes K."xsd:string |
| http://purl.uniprot.org/citations/34402812 | http://purl.uniprot.org/core/author | "Zhou H."xsd:string |
| http://purl.uniprot.org/citations/34402812 | http://purl.uniprot.org/core/author | "Wang B."xsd:string |
| http://purl.uniprot.org/citations/34402812 | http://purl.uniprot.org/core/author | "Zhao W."xsd:string |
| http://purl.uniprot.org/citations/34402812 | http://purl.uniprot.org/core/author | "Shen K."xsd:string |
| http://purl.uniprot.org/citations/34402812 | http://purl.uniprot.org/core/author | "Yen D."xsd:string |
| http://purl.uniprot.org/citations/34402812 | http://purl.uniprot.org/core/author | "Bramlett C."xsd:string |
| http://purl.uniprot.org/citations/34402812 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34402812 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/34402812 | http://purl.uniprot.org/core/pages | "e202010118"xsd:string |
| http://purl.uniprot.org/citations/34402812 | http://purl.uniprot.org/core/title | "Membrane-bound SCF and VCAM-1 synergistically regulate the morphology of hematopoietic stem cells."xsd:string |
| http://purl.uniprot.org/citations/34402812 | http://purl.uniprot.org/core/volume | "220"xsd:string |
| http://purl.uniprot.org/citations/34402812 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34402812 |
| http://purl.uniprot.org/citations/34402812 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34402812 |
| http://purl.uniprot.org/uniprot/#_P29533-mappedCitation-34402812 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34402812 |
| http://purl.uniprot.org/uniprot/#_Q3TR98-mappedCitation-34402812 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34402812 |
| http://purl.uniprot.org/uniprot/#_Q8K0X1-mappedCitation-34402812 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34402812 |
| http://purl.uniprot.org/uniprot/#_Q3UPN1-mappedCitation-34402812 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34402812 |
| http://purl.uniprot.org/uniprot/#_Q91X98-mappedCitation-34402812 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34402812 |
| http://purl.uniprot.org/uniprot/#_Q544V4-mappedCitation-34402812 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34402812 |