| http://purl.uniprot.org/citations/34407406 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34407406 | http://www.w3.org/2000/01/rdf-schema#comment | "Rapid removal of histone H2A.Z from neuronal chromatin is a key step in learning-induced gene expression and memory formation, but mechanisms underlying learning-induced H2A.Z removal are unclear. Anp32e was recently identified as an H2A.Z-specific histone chaperone that removes H2A.Z from nucleosomes in dividing cells, but its role in non-dividing neurons is unclear. Moreover, prior studies investigated Anp32e function under steady-state rather than stimulus-induced conditions. Here, we show that Anp32e regulates H2A.Z binding in neurons under steady-state conditions, with lesser impact on stimulus-induced H2A.Z removal. Functionally, Anp32e depletion leads to H2A.Z-dependent impairment in transcription and dendritic arborization in cultured hippocampal neurons, as well as impaired recall of contextual fear memory and transcriptional regulation. Together, these data indicate that Anp32e regulates behavioral and morphological outcomes by preventing H2A.Z accumulation in chromatin rather than by regulating activity-mediated H2A.Z dynamics."xsd:string |
| http://purl.uniprot.org/citations/34407406 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2021.109551"xsd:string |
| http://purl.uniprot.org/citations/34407406 | http://purl.uniprot.org/core/author | "Hall M."xsd:string |
| http://purl.uniprot.org/citations/34407406 | http://purl.uniprot.org/core/author | "Baumbach J."xsd:string |
| http://purl.uniprot.org/citations/34407406 | http://purl.uniprot.org/core/author | "Murphy P.J."xsd:string |
| http://purl.uniprot.org/citations/34407406 | http://purl.uniprot.org/core/author | "Brimble M.A."xsd:string |
| http://purl.uniprot.org/citations/34407406 | http://purl.uniprot.org/core/author | "Greer C.B."xsd:string |
| http://purl.uniprot.org/citations/34407406 | http://purl.uniprot.org/core/author | "Walters B.J."xsd:string |
| http://purl.uniprot.org/citations/34407406 | http://purl.uniprot.org/core/author | "Davidoff A.M."xsd:string |
| http://purl.uniprot.org/citations/34407406 | http://purl.uniprot.org/core/author | "Stefanelli G."xsd:string |
| http://purl.uniprot.org/citations/34407406 | http://purl.uniprot.org/core/author | "Reda A."xsd:string |
| http://purl.uniprot.org/citations/34407406 | http://purl.uniprot.org/core/author | "Zovkic I.B."xsd:string |
| http://purl.uniprot.org/citations/34407406 | http://purl.uniprot.org/core/author | "Creighton S.D."xsd:string |
| http://purl.uniprot.org/citations/34407406 | http://purl.uniprot.org/core/author | "Makowski C.E."xsd:string |
| http://purl.uniprot.org/citations/34407406 | http://purl.uniprot.org/core/author | "Leonetti A.M."xsd:string |
| http://purl.uniprot.org/citations/34407406 | http://purl.uniprot.org/core/author | "McLean T.A.B."xsd:string |
| http://purl.uniprot.org/citations/34407406 | http://purl.uniprot.org/core/author | "Zakaria J.M."xsd:string |
| http://purl.uniprot.org/citations/34407406 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34407406 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/34407406 | http://purl.uniprot.org/core/pages | "109551"xsd:string |
| http://purl.uniprot.org/citations/34407406 | http://purl.uniprot.org/core/title | "The histone chaperone Anp32e regulates memory formation, transcription, and dendritic morphology by regulating steady-state H2A.Z binding in neurons."xsd:string |
| http://purl.uniprot.org/citations/34407406 | http://purl.uniprot.org/core/volume | "36"xsd:string |
| http://purl.uniprot.org/citations/34407406 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34407406 |
| http://purl.uniprot.org/citations/34407406 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34407406 |