Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/34410246http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/34410246http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To determine the association of Factor V Leiden / prothrombin gene mutation in Pakistani women with adverse pregnancy outcomes.

Method

The prospective study was conducted at the Aga Khan University Hospital, Karachi, from January 1 to December 31, 2016, and comprised females > 40 years having history of two or more foetal losses with no apparent aetiology. Restriction fragment length polymorphism-Polymerase chain reaction was performed using MnlI and HindIII restriction enzymes for factor V Leiden G1691A and prothrombin gene mutation G20210A. Females with two or more consecutive normal pregnancies were enrolled as the control group. Data was analysed using SPSS 19.

Results

Of the 172 participants with a mean age of 29.3±5.9 years (range: 19-38 years). 86(50%) each were healthy controls and those with recurrent pregnancy loss. There were 238 livebirths among the controls compared to 13 in the other group. Factor V Leiden G1691A was identified in 2(2.3%) women, and prothrombin gene mutation G20210A in 1(1.2%) woman in the patient group, while no mutation was identified in the control group.

Conclusions

The prevalence of Factor V Leiden / prothrombin gene mutation in women with recurrent pregnancy loss was found to be very low."xsd:string
http://purl.uniprot.org/citations/34410246http://purl.org/dc/terms/identifier"doi:10.47391/jpma.1377"xsd:string
http://purl.uniprot.org/citations/34410246http://purl.uniprot.org/core/author"Ali S.A."xsd:string
http://purl.uniprot.org/citations/34410246http://purl.uniprot.org/core/author"Moiz B."xsd:string
http://purl.uniprot.org/citations/34410246http://purl.uniprot.org/core/author"Sheikh L."xsd:string
http://purl.uniprot.org/citations/34410246http://purl.uniprot.org/core/date"2021"xsd:gYear
http://purl.uniprot.org/citations/34410246http://purl.uniprot.org/core/name"J Pak Med Assoc"xsd:string
http://purl.uniprot.org/citations/34410246http://purl.uniprot.org/core/pages"1780-1784"xsd:string
http://purl.uniprot.org/citations/34410246http://purl.uniprot.org/core/title"Association of Factor V Leiden G1691A and Prothrombin gene G20210A mutations with adverse pregnancy outcomes."xsd:string
http://purl.uniprot.org/citations/34410246http://purl.uniprot.org/core/volume"71"xsd:string
http://purl.uniprot.org/citations/34410246http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/34410246
http://purl.uniprot.org/citations/34410246http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/34410246
http://purl.uniprot.org/uniprot/#_Q1L610-mappedCitation-34410246http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/34410246
http://purl.uniprot.org/uniprot/#_A0A4V1DVZ0-mappedCitation-34410246http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/34410246
http://purl.uniprot.org/uniprot/#_A0A4P8D7E0-mappedCitation-34410246http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/34410246
http://purl.uniprot.org/uniprot/#_A0A4P8D7E7-mappedCitation-34410246http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/34410246
http://purl.uniprot.org/uniprot/#_B4DU26-mappedCitation-34410246http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/34410246
http://purl.uniprot.org/uniprot/#_C8C1T0-mappedCitation-34410246http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/34410246
http://purl.uniprot.org/uniprot/#_C8C1T1-mappedCitation-34410246http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/34410246
http://purl.uniprot.org/uniprot/#_Q15430-mappedCitation-34410246http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/34410246
http://purl.uniprot.org/uniprot/#_F6MG31-mappedCitation-34410246http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/34410246
http://purl.uniprot.org/uniprot/#_Q2HZZ0-mappedCitation-34410246http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/34410246
http://purl.uniprot.org/uniprot/#_Q2HZZ1-mappedCitation-34410246http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/34410246
http://purl.uniprot.org/uniprot/#_Q2I258-mappedCitation-34410246http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/34410246
▶