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Background

Mitochondrial dysfunction has been suggested to play an important role in all stages of multiple sclerosis (MS).

Objective

To determine the expression of two mitophagy-related proteins, PTEN-induced kinase 1 (PINK1) and PARKIN, in a cohort of Japanese patients with different neuroinflammatory disorders.

Methods

Protein concentrations were measured using commercial ELISA in paired cerebrospinal fluid (CSF) and serum samples from patients with multiple sclerosis (MS), neuromyelitis optica spectrum disorders (NMOSD), and myelin oligodendrocyte glycoprotein antibody disorders (MOGAD), and from age- and sex-matched controls.

Results

CSF and serum concentrations of PINK1 were higher in patients with MS than in patients with NMOSD (p = 0.004 and p < 0.001, respectively), MOGAD (p = 0.008 and p = 0.011, respectively), and controls (p = 0.021 and p = 0.002, respectively). CSF and concentrations of PARKIN were elevated in patients with MS in comparison with those in controls (p = 0.016 and p = 0.05, respectively).

Conclusions

Our study highlighted the importance of mitophagy in MS and suggested the potential application of PINK1 and PARKIN as biomarkers to predict disease activity."xsd:string
http://purl.uniprot.org/citations/34421896http://purl.org/dc/terms/identifier"doi:10.3389/fimmu.2021.681386"xsd:string
http://purl.uniprot.org/citations/34421896http://purl.uniprot.org/core/author"Yokoyama K."xsd:string
http://purl.uniprot.org/citations/34421896http://purl.uniprot.org/core/author"Hattori N."xsd:string
http://purl.uniprot.org/citations/34421896http://purl.uniprot.org/core/author"Sechi L.A."xsd:string
http://purl.uniprot.org/citations/34421896http://purl.uniprot.org/core/author"Cossu D."xsd:string
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http://purl.uniprot.org/citations/34421896http://purl.uniprot.org/core/name"Front Immunol"xsd:string
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http://purl.uniprot.org/citations/34421896http://purl.uniprot.org/core/title"Potential of PINK1 and PARKIN Proteins as Biomarkers for Active Multiple Sclerosis: A Japanese Cohort Study."xsd:string
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