| http://purl.uniprot.org/citations/34433025 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34433025 | http://www.w3.org/2000/01/rdf-schema#comment | "Sustained activation of the Ca2+-release-activated Ca2+ (CRAC) channel is pivotal for effector T cell responses. The mechanisms underlying this sustainability remain poorly understood. We find that plasma membrane localization of ORAI1, the pore subunit of CRAC channels, is limited in effector T cells, with a significant fraction trapped in intracellular vesicles. From a targeted screen, we identify an essential component of ORAI1+ vesicles, naked cuticle homolog 2 (NKD2). Mechanistically, NKD2, an adaptor molecule activated by signaling pathways downstream of T cell receptors, orchestrates trafficking and insertion of ORAI1+ vesicles to the plasma membrane. Together, our findings suggest that T cell receptor (TCR)-stimulation-dependent insertion of ORAI1 into the plasma membrane is essential for sustained Ca2+ signaling and cytokine production in T cells."xsd:string |
| http://purl.uniprot.org/citations/34433025 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2021.109603"xsd:string |
| http://purl.uniprot.org/citations/34433025 | http://purl.uniprot.org/core/author | "Sun Z."xsd:string |
| http://purl.uniprot.org/citations/34433025 | http://purl.uniprot.org/core/author | "Wu B."xsd:string |
| http://purl.uniprot.org/citations/34433025 | http://purl.uniprot.org/core/author | "Woo J.S."xsd:string |
| http://purl.uniprot.org/citations/34433025 | http://purl.uniprot.org/core/author | "Leung J."xsd:string |
| http://purl.uniprot.org/citations/34433025 | http://purl.uniprot.org/core/author | "Gwack Y."xsd:string |
| http://purl.uniprot.org/citations/34433025 | http://purl.uniprot.org/core/author | "Jew M."xsd:string |
| http://purl.uniprot.org/citations/34433025 | http://purl.uniprot.org/core/author | "Srikanth S."xsd:string |
| http://purl.uniprot.org/citations/34433025 | http://purl.uniprot.org/core/author | "Vila P."xsd:string |
| http://purl.uniprot.org/citations/34433025 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34433025 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/34433025 | http://purl.uniprot.org/core/pages | "109603"xsd:string |
| http://purl.uniprot.org/citations/34433025 | http://purl.uniprot.org/core/title | "NKD2 mediates stimulation-dependent ORAI1 trafficking to augment Capisup>2+pi/sup> entry in T cells."xsd:string |
| http://purl.uniprot.org/citations/34433025 | http://purl.uniprot.org/core/volume | "36"xsd:string |
| http://purl.uniprot.org/citations/34433025 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34433025 |
| http://purl.uniprot.org/citations/34433025 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34433025 |
| http://purl.uniprot.org/uniprot/#_Q969F2-mappedCitation-34433025 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34433025 |
| http://purl.uniprot.org/uniprot/#_Q96D31-mappedCitation-34433025 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34433025 |
| http://purl.uniprot.org/uniprot/Q969F2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/34433025 |
| http://purl.uniprot.org/uniprot/Q96D31 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/34433025 |