| http://purl.uniprot.org/citations/34437534 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34437534 | http://www.w3.org/2000/01/rdf-schema#comment | "Tumor necrosis factor receptor-1 (TNFR1) signaling, apart from its pleiotropic functions in inflammation, plays a role in embryogenesis as deficiency of varieties of its downstream molecules leads to embryonic lethality in mice. Caspase-8 noncleavable receptor interacting serine/threonine kinase 1 (RIPK1) mutations occur naturally in humans, and the corresponding D325A mutation in murine RIPK1 leads to death at early midgestation. It is known that both the demise of Ripk1D325A/D325A embryos and the death of Casp8-/-mice are initiated by TNFR1, but they are mediated by apoptosis and necroptosis, respectively. Here, we show that the defects in Ripk1D325A/D325A embryos occur at embryonic day 10.5 (E10.5), earlier than that caused by Casp8 knockout. By analyzing a series of genetically mutated mice, we elucidated a mechanism that leads to the lethality of Ripk1D325A/D325A embryos and compared it with that underlies Casp8 deletion-mediated lethality. We revealed that the apoptosis in Ripk1D325A/D325A embryos requires a scaffold function of RIPK3 and enzymatically active caspase-8. Unexpectedly, caspase-1 and caspase-11 are downstream of activated caspase-8, and concurrent depletion of Casp1 and Casp11 postpones the E10.5 lethality to embryonic day 13.5 (E13.5). Moreover, caspase-3 is an executioner of apoptosis at E10.5 in Ripk1D325A/D325A mice as its deletion extends life of Ripk1D325A/D325A mice to embryonic day 11.5 (E11.5). Hence, an unexpected death pathway of TNFR1 controls RIPK1 D325A mutation-induced lethality at E10.5."xsd:string |
| http://purl.uniprot.org/citations/34437534 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pbio.3001304"xsd:string |
| http://purl.uniprot.org/citations/34437534 | http://purl.uniprot.org/core/author | "Han J."xsd:string |
| http://purl.uniprot.org/citations/34437534 | http://purl.uniprot.org/core/author | "Han W."xsd:string |
| http://purl.uniprot.org/citations/34437534 | http://purl.uniprot.org/core/author | "Huang K."xsd:string |
| http://purl.uniprot.org/citations/34437534 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
| http://purl.uniprot.org/citations/34437534 | http://purl.uniprot.org/core/author | "Liu J."xsd:string |
| http://purl.uniprot.org/citations/34437534 | http://purl.uniprot.org/core/author | "Song J."xsd:string |
| http://purl.uniprot.org/citations/34437534 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/34437534 | http://purl.uniprot.org/core/author | "Shi W."xsd:string |
| http://purl.uniprot.org/citations/34437534 | http://purl.uniprot.org/core/author | "Zhang Y.'"xsd:string |
| http://purl.uniprot.org/citations/34437534 | http://purl.uniprot.org/core/author | "Han T."xsd:string |
| http://purl.uniprot.org/citations/34437534 | http://purl.uniprot.org/core/author | "Sun Y.H."xsd:string |
| http://purl.uniprot.org/citations/34437534 | http://purl.uniprot.org/core/author | "Ruan C."xsd:string |
| http://purl.uniprot.org/citations/34437534 | http://purl.uniprot.org/core/author | "Wu S.Q."xsd:string |
| http://purl.uniprot.org/citations/34437534 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34437534 | http://purl.uniprot.org/core/name | "PLoS Biol"xsd:string |
| http://purl.uniprot.org/citations/34437534 | http://purl.uniprot.org/core/pages | "e3001304"xsd:string |
| http://purl.uniprot.org/citations/34437534 | http://purl.uniprot.org/core/title | "A unique death pathway keeps RIPK1 D325A mutant mice in check at embryonic day 10.5."xsd:string |
| http://purl.uniprot.org/citations/34437534 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/34437534 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34437534 |
| http://purl.uniprot.org/citations/34437534 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34437534 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGK6-mappedCitation-34437534 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34437534 |
| http://purl.uniprot.org/uniprot/#_A0A087WQT6-mappedCitation-34437534 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34437534 |