| http://purl.uniprot.org/citations/34445261 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34445261 | http://www.w3.org/2000/01/rdf-schema#comment | "The current treatment options for type 2 diabetes mellitus do not adequately control the disease in many patients. Consequently, there is a need for new drugs to prevent and treat type 2 diabetes mellitus. Among the new potential pharmacological strategies, activators of peroxisome proliferator-activated receptor (PPAR)β/δ show promise. Remarkably, most of the antidiabetic effects of PPARβ/δ agonists involve AMP-activated protein kinase (AMPK) activation. This review summarizes the recent mechanistic insights into the antidiabetic effects of the PPARβ/δ-AMPK pathway, including the upregulation of glucose uptake, muscle remodeling, enhanced fatty acid oxidation, and autophagy, as well as the inhibition of endoplasmic reticulum stress and inflammation. A better understanding of the mechanisms underlying the effects resulting from the PPARβ/δ-AMPK pathway may provide the basis for the development of new therapies in the prevention and treatment of insulin resistance and type 2 diabetes mellitus."xsd:string |
| http://purl.uniprot.org/citations/34445261 | http://purl.org/dc/terms/identifier | "doi:10.3390/ijms22168555"xsd:string |
| http://purl.uniprot.org/citations/34445261 | http://purl.uniprot.org/core/author | "Wahli W."xsd:string |
| http://purl.uniprot.org/citations/34445261 | http://purl.uniprot.org/core/author | "Palomer X."xsd:string |
| http://purl.uniprot.org/citations/34445261 | http://purl.uniprot.org/core/author | "Vazquez-Carrera M."xsd:string |
| http://purl.uniprot.org/citations/34445261 | http://purl.uniprot.org/core/author | "Aguilar-Recarte D."xsd:string |
| http://purl.uniprot.org/citations/34445261 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34445261 | http://purl.uniprot.org/core/name | "Int J Mol Sci"xsd:string |
| http://purl.uniprot.org/citations/34445261 | http://purl.uniprot.org/core/pages | "8555"xsd:string |
| http://purl.uniprot.org/citations/34445261 | http://purl.uniprot.org/core/title | "The PPARbeta/delta-AMPK Connection in the Treatment of Insulin Resistance."xsd:string |
| http://purl.uniprot.org/citations/34445261 | http://purl.uniprot.org/core/volume | "22"xsd:string |
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