| http://purl.uniprot.org/citations/34445387 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34445387 | http://www.w3.org/2000/01/rdf-schema#comment | "Prostate cancer (PCa) is the leading cause of cancer-associated mortality in men, and new biomarkers are still needed. The expression pattern and protein tissue localization of proteoglycans of the syndecan family (SDC 1-4) and syntenin-1 (SDCBP) were determined in normal and prostatic tumor tissue from two genetically engineered mouse models and human prostate tumors. Studies were validated using SDC 1-4 and SDCBP mRNA levels and patient survival data from The Cancer Genome Atlas and CamCAP databases. RNAseq showed increased expression of Sdc1 in Pb-Cre4/Ptenf/f mouse Pca and upregulation of Sdc3 expression and downregulation of Sdc2 and Sdc4 when compared to the normal prostatic tissue in Pb-Cre4/Trp53f/f-;Rb1f/f mouse tumors. These changes were confirmed by immunohistochemistry. In human PCa, SDC 1-4 and SDCBP immunostaining showed variable localization. Furthermore, Kaplan-Meier analysis showed that patients expressing SDC3 had shorter prostate-specific survival than those without SDC3 expression (log-rank test, p = 0.0047). Analysis of the MSKCC-derived expression showed that SDC1 and SDC3 overexpression is predictive of decreased biochemical recurrence-free survival (p = 0.0099 and p = 0.045, respectively), and SDC4 overexpression is predictive of increased biochemical recurrence-free survival (p = 0.035). SDC4 overexpression was associated with a better prognosis, while SDC1 and SDC3 were associated with more aggressive tumors and a worse prognosis."xsd:string |
| http://purl.uniprot.org/citations/34445387 | http://purl.org/dc/terms/identifier | "doi:10.3390/ijms22168669"xsd:string |
| http://purl.uniprot.org/citations/34445387 | http://purl.uniprot.org/core/author | "Barbosa I.C."xsd:string |
| http://purl.uniprot.org/citations/34445387 | http://purl.uniprot.org/core/author | "Barbosa G.O."xsd:string |
| http://purl.uniprot.org/citations/34445387 | http://purl.uniprot.org/core/author | "Carvalho H.F."xsd:string |
| http://purl.uniprot.org/citations/34445387 | http://purl.uniprot.org/core/author | "Felisbino S.L."xsd:string |
| http://purl.uniprot.org/citations/34445387 | http://purl.uniprot.org/core/author | "Santos N.J."xsd:string |
| http://purl.uniprot.org/citations/34445387 | http://purl.uniprot.org/core/author | "Lima F.O."xsd:string |
| http://purl.uniprot.org/citations/34445387 | http://purl.uniprot.org/core/author | "Barquilha C.N."xsd:string |
| http://purl.uniprot.org/citations/34445387 | http://purl.uniprot.org/core/author | "Justulin L.A."xsd:string |
| http://purl.uniprot.org/citations/34445387 | http://purl.uniprot.org/core/author | "Macedo R.T."xsd:string |
| http://purl.uniprot.org/citations/34445387 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34445387 | http://purl.uniprot.org/core/name | "Int J Mol Sci"xsd:string |
| http://purl.uniprot.org/citations/34445387 | http://purl.uniprot.org/core/pages | "8669"xsd:string |
| http://purl.uniprot.org/citations/34445387 | http://purl.uniprot.org/core/title | "Syndecan Family Gene and Protein Expression and Their Prognostic Values for Prostate Cancer."xsd:string |
| http://purl.uniprot.org/citations/34445387 | http://purl.uniprot.org/core/volume | "22"xsd:string |
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