| http://purl.uniprot.org/citations/34460096 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34460096 | http://www.w3.org/2000/01/rdf-schema#comment | "Acidity in the tumor microenvironment has been reported to promote cancer growth and metastasis. In our study, we examined a potential relation between extracellular acidity and expression level of the immune checkpoint molecule programmed cell death protein 1 (PD-L1) in murine squamous cell carcinoma (SCC) and melanoma cell lines. PD-L1 expression in the tumor cells was upregulated by culturing in a low pH culture medium. Tumor-bearing mice were allowed to ingest sodium bicarbonate, resulting in neutralization of acidity in the tumor tissue, a decrease in PD-L1 expression in tumor cells and suppression of tumor growth in vivo. Proton-sensing G protein-coupled receptors, T-cell death-associated gene 8 (TDAG8) and ovarian cancer G-protein-coupled receptor 1 (OGR1), were upregulated by low pH, and essentially involved in the acidity-induced elevation of PD-L1 expression in the tumor cells. Human head and neck SCC RNAseq data from the Cancer Genome Atlas also suggested a statistically significant correlation between expression levels of the proton sensors and PD-L1 mRNA expression. These findings strongly suggest that neutralization of acidity in tumor tissue may result in reduction of PD-L1 expression, potentially leading to inhibition of an immune checkpoint and augmentation of antitumor immunity."xsd:string |
| http://purl.uniprot.org/citations/34460096 | http://purl.org/dc/terms/identifier | "doi:10.1002/ijc.33786"xsd:string |
| http://purl.uniprot.org/citations/34460096 | http://purl.uniprot.org/core/author | "Hirano S."xsd:string |
| http://purl.uniprot.org/citations/34460096 | http://purl.uniprot.org/core/author | "Sugiyama Y."xsd:string |
| http://purl.uniprot.org/citations/34460096 | http://purl.uniprot.org/core/author | "Kawaguchi T."xsd:string |
| http://purl.uniprot.org/citations/34460096 | http://purl.uniprot.org/core/author | "Arai A."xsd:string |
| http://purl.uniprot.org/citations/34460096 | http://purl.uniprot.org/core/author | "Mori D."xsd:string |
| http://purl.uniprot.org/citations/34460096 | http://purl.uniprot.org/core/author | "Fuse S."xsd:string |
| http://purl.uniprot.org/citations/34460096 | http://purl.uniprot.org/core/author | "Mazda O."xsd:string |
| http://purl.uniprot.org/citations/34460096 | http://purl.uniprot.org/core/author | "Kishida T."xsd:string |
| http://purl.uniprot.org/citations/34460096 | http://purl.uniprot.org/core/author | "Tsujikawa T."xsd:string |
| http://purl.uniprot.org/citations/34460096 | http://purl.uniprot.org/core/author | "Ohmura G."xsd:string |
| http://purl.uniprot.org/citations/34460096 | http://purl.uniprot.org/core/author | "Kotani S.I."xsd:string |
| http://purl.uniprot.org/citations/34460096 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34460096 | http://purl.uniprot.org/core/name | "Int J Cancer"xsd:string |
| http://purl.uniprot.org/citations/34460096 | http://purl.uniprot.org/core/pages | "2116-2124"xsd:string |
| http://purl.uniprot.org/citations/34460096 | http://purl.uniprot.org/core/title | "Extracellular acidity in tumor tissue upregulates programmed cell death protein 1 expression on tumor cells via proton-sensing G protein-coupled receptors."xsd:string |
| http://purl.uniprot.org/citations/34460096 | http://purl.uniprot.org/core/volume | "149"xsd:string |
| http://purl.uniprot.org/citations/34460096 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34460096 |
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| http://purl.uniprot.org/uniprot/#_Q3UZ41-mappedCitation-34460096 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34460096 |