| http://purl.uniprot.org/citations/34461107 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34461107 | http://www.w3.org/2000/01/rdf-schema#comment | "CD4+CD25+ regulatory T (Treg) cells and Th17 cells play important roles in the progression of metabolic-associated fatty liver disease (MAFLD). However, the contribution of monokine induced by interferon-gamma (MIG)/CXCL9 to the Treg/Th17 imbalance in MAFLD is only partially understood. In the present study, we detected increased levels of MIG/CXCL9 and a Treg/Th17 imbalance in the setting of metabolic-associated steatohepatitis (MASH). Recombinant adeno-associated virus-mediated gene transfer and silencing of MIG/CXCL9 expression in mice alleviated MASH and increased the Treg/Th17 ratio. Furthermore, the percentage of Th17 cells, but not Treg cells, differentiated from splenic CD4+ T cells was significantly increased by administration of MIG/CXCL9. MIG/CXCL9 also promoted Th17 cell proliferation, and its effects were dose dependent. Levels of phosphorylated c-Jun N-terminal kinase (JNK) decreased dramatically when MIG/CXCL9 was inhibited in a murine MASH model. In cultured Treg cells, phosphorylated JNK levels decreased dose-dependently in response to MIG/CXCL9 inhibition, but increased in cultured Th17 cells. This effect was blocked in the presence of a JNK inhibitor. These findings underline the fundamental importance of MIG/CXCL9 in maintaining the Treg/Th17 balance in MAFLD and provide the foundations for a novel approach to preventing and treating MAFLD."xsd:string |
| http://purl.uniprot.org/citations/34461107 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.yexcr.2021.112801"xsd:string |
| http://purl.uniprot.org/citations/34461107 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
| http://purl.uniprot.org/citations/34461107 | http://purl.uniprot.org/core/author | "Liu M."xsd:string |
| http://purl.uniprot.org/citations/34461107 | http://purl.uniprot.org/core/author | "Wang D."xsd:string |
| http://purl.uniprot.org/citations/34461107 | http://purl.uniprot.org/core/author | "Zhang Z."xsd:string |
| http://purl.uniprot.org/citations/34461107 | http://purl.uniprot.org/core/author | "Xia Y."xsd:string |
| http://purl.uniprot.org/citations/34461107 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/34461107 | http://purl.uniprot.org/core/author | "Ji X."xsd:string |
| http://purl.uniprot.org/citations/34461107 | http://purl.uniprot.org/core/author | "Lu P."xsd:string |
| http://purl.uniprot.org/citations/34461107 | http://purl.uniprot.org/core/author | "Ding Q."xsd:string |
| http://purl.uniprot.org/citations/34461107 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34461107 | http://purl.uniprot.org/core/name | "Exp Cell Res"xsd:string |
| http://purl.uniprot.org/citations/34461107 | http://purl.uniprot.org/core/pages | "112801"xsd:string |
| http://purl.uniprot.org/citations/34461107 | http://purl.uniprot.org/core/title | "MIG/CXCL9 exacerbates the progression of metabolic-associated fatty liver disease by disrupting Treg/Th17 balance."xsd:string |
| http://purl.uniprot.org/citations/34461107 | http://purl.uniprot.org/core/volume | "407"xsd:string |
| http://purl.uniprot.org/citations/34461107 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34461107 |
| http://purl.uniprot.org/citations/34461107 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34461107 |
| http://purl.uniprot.org/uniprot/#_B2R4J7-mappedCitation-34461107 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34461107 |
| http://purl.uniprot.org/uniprot/#_Q07325-mappedCitation-34461107 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34461107 |
| http://purl.uniprot.org/uniprot/#_P18340-mappedCitation-34461107 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34461107 |
| http://purl.uniprot.org/uniprot/#_Q3U089-mappedCitation-34461107 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34461107 |
| http://purl.uniprot.org/uniprot/#_Q91ZB2-mappedCitation-34461107 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34461107 |
| http://purl.uniprot.org/uniprot/#_Q8C9B8-mappedCitation-34461107 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34461107 |