| http://purl.uniprot.org/citations/34462459 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34462459 | http://www.w3.org/2000/01/rdf-schema#comment | "T-bet is a key transcription factor for the T helper 1 lineage and its expression level is negatively correlated to inflammation in patients with rheumatoid arthritis (RA). Our previous study using T-bet transgenic mice revealed over-expression of T-bet completely suppressed collagen-induced arthritis (CIA), a murine model of RA, indicating a potential suppressive role of T-bet in the pathogenesis of autoimmune arthritis. Here, we show T-bet-deficiency exacerbated CIA. T-bet in CD4 + T cells, but not in CD11c + dendritic cells, was critical for regulating the production of IL-17A, IL-17F, IL-22, and TNFα from CD4 + T cells. T-bet-deficient CD4 + T cells showed higher RORγt expression and increased IL-17A production in RORγt-positive cells after CII immunization. In addition, T-bet-deficient naïve CD4 + T cells showed accelerated Th17 differentiation in vitro. CIA induced in CD4-Cre T-betfl/fl (cKO) mice was more severe and T-bet-deficient CD4 + T cells in the arthritic joints of cKO mice showed higher RORγt expression and increased IL-17A production. Transcriptome analysis of T-bet-deficient CD4 + T cells revealed that expression levels of Th17-related genes were selectively increased. Our results indicate that T-bet in CD4 + T cells repressed RORγt expression and function resulting in suppression of arthritogenic Th17 cells and CIA."xsd:string |
| http://purl.uniprot.org/citations/34462459 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-021-96699-5"xsd:string |
| http://purl.uniprot.org/citations/34462459 | http://purl.uniprot.org/core/author | "Kondo Y."xsd:string |
| http://purl.uniprot.org/citations/34462459 | http://purl.uniprot.org/core/author | "Shimizu M."xsd:string |
| http://purl.uniprot.org/citations/34462459 | http://purl.uniprot.org/core/author | "Sumida T."xsd:string |
| http://purl.uniprot.org/citations/34462459 | http://purl.uniprot.org/core/author | "Matsumoto I."xsd:string |
| http://purl.uniprot.org/citations/34462459 | http://purl.uniprot.org/core/author | "Tsuboi H."xsd:string |
| http://purl.uniprot.org/citations/34462459 | http://purl.uniprot.org/core/author | "Tanimura R."xsd:string |
| http://purl.uniprot.org/citations/34462459 | http://purl.uniprot.org/core/author | "Furuyama K."xsd:string |
| http://purl.uniprot.org/citations/34462459 | http://purl.uniprot.org/core/author | "Yokosawa M."xsd:string |
| http://purl.uniprot.org/citations/34462459 | http://purl.uniprot.org/core/author | "Asashima H."xsd:string |
| http://purl.uniprot.org/citations/34462459 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34462459 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/34462459 | http://purl.uniprot.org/core/pages | "17357"xsd:string |
| http://purl.uniprot.org/citations/34462459 | http://purl.uniprot.org/core/title | "T-bet represses collagen-induced arthritis by suppressing Th17 lineage commitment through inhibition of RORgammat expression and function."xsd:string |
| http://purl.uniprot.org/citations/34462459 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/34462459 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34462459 |
| http://purl.uniprot.org/citations/34462459 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34462459 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGZ6-mappedCitation-34462459 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34462459 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J096-mappedCitation-34462459 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34462459 |
| http://purl.uniprot.org/uniprot/#_Q3UUW3-mappedCitation-34462459 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34462459 |
| http://purl.uniprot.org/uniprot/#_Q5PSB0-mappedCitation-34462459 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34462459 |
| http://purl.uniprot.org/uniprot/#_P51450-mappedCitation-34462459 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34462459 |
| http://purl.uniprot.org/uniprot/#_Q3TVH3-mappedCitation-34462459 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34462459 |