| http://purl.uniprot.org/citations/34468993 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34468993 | http://www.w3.org/2000/01/rdf-schema#comment | "Circular RNA E2F transcription factor 3 (circ-E2F3) has been demonstrated to be differentially expressed in some diseases and cancers. However, the role of circ-E2F3 in cervical cancer (CC) progression remains unclear. Therefore, we aimed to elucidate the mechanism of circ-E2F3 regulation of CC progression. Circ-E2F3 expression was determined in CC samples, and its correlation with the clinicopathological characteristics of CC patients and cell biological processes was examined. The interaction among circ-E2F3, microRNA-296-5p (miR-296-5p), and signal transducer and activator of transcription 3 (STAT3) was analyzed by dual luciferase reporter gene and fluorescence in situ hybridization assays. Circ-E2F3-depleted CaSki cells were implanted into nude mice to verify the function of circ-E2F3 in vivo. Circ-E2F3 was upregulated in both CC tissues and cell lines, and this correlated with the clinicopathological features and poor prognosis of CC patients. Moreover, circ-E2F3 promoted the proliferation, invasion, and migration of CC cells and tumor growth in vivo. It was also observed that circ-E2F3 promoted the nuclear translocation of STAT3 through inhibition of miR-296-5p, thus affecting the expression of cyclin D1. Taken together, the key findings of our study demonstrate that circ-E2F3 induces inhibition of miR-296-5p, which triggers activation and nuclear translocation of STAT3 that then upregulates cyclin D1 expression."xsd:string |
| http://purl.uniprot.org/citations/34468993 | http://purl.org/dc/terms/identifier | "doi:10.1111/nyas.14653"xsd:string |
| http://purl.uniprot.org/citations/34468993 | http://purl.uniprot.org/core/author | "Cao X."xsd:string |
| http://purl.uniprot.org/citations/34468993 | http://purl.uniprot.org/core/author | "Qian Q."xsd:string |
| http://purl.uniprot.org/citations/34468993 | http://purl.uniprot.org/core/author | "Xi Y."xsd:string |
| http://purl.uniprot.org/citations/34468993 | http://purl.uniprot.org/core/author | "Wang B."xsd:string |
| http://purl.uniprot.org/citations/34468993 | http://purl.uniprot.org/core/author | "Ma Q."xsd:string |
| http://purl.uniprot.org/citations/34468993 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/34468993 | http://purl.uniprot.org/core/name | "Ann N Y Acad Sci"xsd:string |
| http://purl.uniprot.org/citations/34468993 | http://purl.uniprot.org/core/pages | "84-98"xsd:string |
| http://purl.uniprot.org/citations/34468993 | http://purl.uniprot.org/core/title | "Circ-E2F3 promotes cervical cancer progression by inhibiting microRNA-296-5p and increasing STAT3 nuclear translocation."xsd:string |
| http://purl.uniprot.org/citations/34468993 | http://purl.uniprot.org/core/volume | "1507"xsd:string |
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| http://purl.uniprot.org/uniprot/#_B5BTZ6-mappedCitation-34468993 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34468993 |
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