| http://purl.uniprot.org/citations/34469735 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34469735 | http://www.w3.org/2000/01/rdf-schema#comment | "In holometabolous insects, metamorphic timing and body size are controlled by a neuroendocrine axis composed of the ecdysone-producing prothoracic gland (PG) and its presynaptic neurons (PGNs) producing PTTH. Although PTTH/Torso signaling is considered the primary mediator of metamorphic timing, recent studies indicate that other unidentified PGN-derived factors also affect timing. Here, we demonstrate that the receptor tyrosine kinases anaplastic lymphoma kinase (Alk) and PDGF and VEGF receptor-related (Pvr), function in coordination with PTTH/Torso signaling to regulate pupariation timing and body size. Both Alk and Pvr trigger Ras/Erk signaling in the PG to upregulate expression of ecdysone biosynthetic enzymes, while Alk also suppresses autophagy by activating phosphatidylinositol 3-kinase (PI3K)/Akt. The Alk ligand Jelly belly (Jeb) is produced by the PGNs and serves as a second PGN-derived tropic factor, while Pvr activation mainly relies on autocrine signaling by PG-derived Pvf2 and Pvf3. These findings illustrate that a combination of juxtacrine and autocrine signaling regulates metamorphic timing, the defining event of holometabolous development."xsd:string |
| http://purl.uniprot.org/citations/34469735 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2021.109644"xsd:string |
| http://purl.uniprot.org/citations/34469735 | http://purl.uniprot.org/core/author | "Pan X."xsd:string |
| http://purl.uniprot.org/citations/34469735 | http://purl.uniprot.org/core/author | "O'Connor M.B."xsd:string |
| http://purl.uniprot.org/citations/34469735 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34469735 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/34469735 | http://purl.uniprot.org/core/pages | "109644"xsd:string |
| http://purl.uniprot.org/citations/34469735 | http://purl.uniprot.org/core/title | "Coordination among multiple receptor tyrosine kinase signals controls Drosophila developmental timing and body size."xsd:string |
| http://purl.uniprot.org/citations/34469735 | http://purl.uniprot.org/core/volume | "36"xsd:string |
| http://purl.uniprot.org/citations/34469735 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34469735 |
| http://purl.uniprot.org/citations/34469735 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34469735 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHS6-mappedCitation-34469735 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34469735 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHS7-mappedCitation-34469735 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34469735 |
| http://purl.uniprot.org/uniprot/#_A0A0B4LF75-mappedCitation-34469735 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34469735 |
| http://purl.uniprot.org/uniprot/#_E1JHA2-mappedCitation-34469735 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34469735 |
| http://purl.uniprot.org/uniprot/#_E1JHB6-mappedCitation-34469735 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34469735 |
| http://purl.uniprot.org/uniprot/#_E1JHB7-mappedCitation-34469735 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34469735 |
| http://purl.uniprot.org/uniprot/#_E1JHB8-mappedCitation-34469735 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34469735 |
| http://purl.uniprot.org/uniprot/#_Q1JUZ1-mappedCitation-34469735 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34469735 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KH10-mappedCitation-34469735 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34469735 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KGE1-mappedCitation-34469735 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34469735 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KGI7-mappedCitation-34469735 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34469735 |
| http://purl.uniprot.org/uniprot/#_B6IDV6-mappedCitation-34469735 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34469735 |
| http://purl.uniprot.org/uniprot/#_A0A0S0WMK2-mappedCitation-34469735 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34469735 |