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http://purl.uniprot.org/citations/34476481http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
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Context

IGF-I is important for postnatal growth and may be of diagnostic value in infants suspected of pituitary disease; however, little is known about the impact of IGF-I and its determinants on infant growth. Importantly, detailed reference ranges for IGF-I and IGF binding protein-3 (IGFBP-3) concentrations during infancy are lacking.

Objective

To evaluate the rapid changes in weight and length as well as their determinants in healthy infants, and to establish age- and sex-specific reference curves for IGF-I and IGFBP-3 in children aged 0 to 1 years.

Design

Prospective longitudinal study.

Setting

Cohort study.

Participants

A total of 233 healthy children (114 girls) with repeated blood samples during the first year of life.

Main outcome measure(s)

Serum concentrations of IGF-I and IGFBP-3, length velocity, weight velocity, and PAPPA2 (rs1325598) genotype.

Results

Individual trajectories of length and weight velocities were sex specific. We provide detailed reference curves based on longitudinal data for IGF-I and IGFBP-3 during infancy. In both girls and boys, IGF-I decreased during infancy, whereas IGFBP-3 remained stable. IGF-I and IGFBP-3, but not PAPPA2 genotype, were positively associated with weight gain, but not with longitudinal growth. When stratified by sex, the association between weight gain and IGF-I only remained significant in girls.

Conclusions

Interestingly, we found a significant association between IGF-I and infant weight gain in girls, but not with longitudinal growth in the first year of life. Our findings highlight the role of IGF-I as an important anabolic hormone that is not limited to linear growth."xsd:string
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http://purl.uniprot.org/citations/34476481http://purl.uniprot.org/core/author"Jensen R.B."xsd:string
http://purl.uniprot.org/citations/34476481http://purl.uniprot.org/core/author"Petersen J.H."xsd:string
http://purl.uniprot.org/citations/34476481http://purl.uniprot.org/core/author"Almstrup K."xsd:string
http://purl.uniprot.org/citations/34476481http://purl.uniprot.org/core/author"Fischer M.B."xsd:string
http://purl.uniprot.org/citations/34476481http://purl.uniprot.org/core/author"Juul A."xsd:string
http://purl.uniprot.org/citations/34476481http://purl.uniprot.org/core/author"Hagen C.P."xsd:string
http://purl.uniprot.org/citations/34476481http://purl.uniprot.org/core/author"Busch A.S."xsd:string
http://purl.uniprot.org/citations/34476481http://purl.uniprot.org/core/author"Upners E.N."xsd:string
http://purl.uniprot.org/citations/34476481http://purl.uniprot.org/core/author"Ljubicic M.L."xsd:string
http://purl.uniprot.org/citations/34476481http://purl.uniprot.org/core/date"2022"xsd:gYear
http://purl.uniprot.org/citations/34476481http://purl.uniprot.org/core/name"J Clin Endocrinol Metab"xsd:string
http://purl.uniprot.org/citations/34476481http://purl.uniprot.org/core/pages"219-229"xsd:string
http://purl.uniprot.org/citations/34476481http://purl.uniprot.org/core/title"Dynamic Changes in Serum IGF-I and Growth During Infancy: Associations to Body Fat, Target Height, and PAPPA2 Genotype."xsd:string
http://purl.uniprot.org/citations/34476481http://purl.uniprot.org/core/volume"107"xsd:string
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