| http://purl.uniprot.org/citations/34478713 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34478713 | http://www.w3.org/2000/01/rdf-schema#comment | "The CD8αβ heterodimer plays a crucial role in the stabilization between major histocompatibility complex class I molecules (MHC-I) and the T cell receptor (TCR). The interaction between CD8 and MHC-I can be regulated by posttranslational modifications, which are proposed to play an important role in the development of CD8 T cells. One modification that has been proposed to control CD8 coreceptor function is ribosylation. Utilizing NAD+, the ecto-enzyme adenosine diphosphate (ADP) ribosyl transferase 2.2 (ART2.2) catalyzes the addition of ADP-ribosyl groups onto arginine residues of CD8α or β chains and alters the interaction between the MHC and TCR complexes. To date, only interactions between modified CD8 and classical MHC-I (MHC-Ia), have been investigated and the interaction with non-classical MHC (MHC-Ib) has not been explored. Here, we show that ADP-ribosylation of CD8 facilitates the binding of the liver-restricted nonclassical MHC, H2-Q10, independent of the associated TCR or presented peptide, and propose that this highly regulated binding imposes an additional inhibitory leash on the activation of CD8-expressing cells in the presence of NAD+. These findings highlight additional important roles for nonclassical MHC-I in the regulation of immune responses."xsd:string |
| http://purl.uniprot.org/citations/34478713 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jbc.2021.101141"xsd:string |
| http://purl.uniprot.org/citations/34478713 | http://purl.uniprot.org/core/author | "Nguyen A."xsd:string |
| http://purl.uniprot.org/citations/34478713 | http://purl.uniprot.org/core/author | "Andrews D.M."xsd:string |
| http://purl.uniprot.org/citations/34478713 | http://purl.uniprot.org/core/author | "Sullivan L.C."xsd:string |
| http://purl.uniprot.org/citations/34478713 | http://purl.uniprot.org/core/author | "Goodall K.J."xsd:string |
| http://purl.uniprot.org/citations/34478713 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34478713 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/34478713 | http://purl.uniprot.org/core/pages | "101141"xsd:string |
| http://purl.uniprot.org/citations/34478713 | http://purl.uniprot.org/core/title | "Ribosylation of the CD8alphabeta heterodimer permits binding of the nonclassical major histocompatibility molecule, H2-Q10."xsd:string |
| http://purl.uniprot.org/citations/34478713 | http://purl.uniprot.org/core/volume | "297"xsd:string |
| http://purl.uniprot.org/citations/34478713 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34478713 |
| http://purl.uniprot.org/citations/34478713 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34478713 |
| http://purl.uniprot.org/uniprot/#_P10300-mappedCitation-34478713 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34478713 |
| http://purl.uniprot.org/uniprot/#_A0A2Z4T1X3-mappedCitation-34478713 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34478713 |
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| http://purl.uniprot.org/uniprot/#_A0A2Z4SZJ5-mappedCitation-34478713 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34478713 |
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| http://purl.uniprot.org/uniprot/#_Q3UUV7-mappedCitation-34478713 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34478713 |