| http://purl.uniprot.org/citations/34492536 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34492536 | http://www.w3.org/2000/01/rdf-schema#comment | "Severe acute lung injury (ALI) cause significant morbidity and mortality worldwide. MicroRNAs (miRNAs) are possible biomarkers and therapeutic targets for ALI. We aimed to explore the role of miR-762, a known oncogenic factor, in the pathogenesis of ALI. Levels of miR-762 in lung tissues of LPS-treated ALI mice and blood cells of patients with lung injury were measured. Injury of human lung epithelial cell line A549 was induced by LPS stimulation. A downstream target of miR-762, NFIX, was predicted using online tools. Their interactions were validated by luciferase reporter assay. Effects of targeted regulation of the miR-762/NFIX axis on cell proliferation, apoptosis, and inflammatory responses were tested in vitro in A549 cells in vivo with an ALI mouse model. We found that upregulation of miR-762 expression and downregulation of NFIX expression were associated with lung injury. Either miR-762 inhibition or NFIX overexpression in A549 lung cells significantly attenuated LPS-mediated impairment of cell proliferation and viability. Notably, increasing expressions of miR-762 inhibitor or NFIX in vivo via airway lentivirus infection alleviated the LPS-induced ALI in mice. Further, targeted downregulation of miR-762 expression or upregulation of NFIX expression in A549 cells markedly down-regulates NF-κB/IRF3 activation, and substantially reduces the production of inflammatory factors, including TNF-α, IL-6, and IL-8. This study reveals a novel role for the miR-762/NFIX pathway in ALI pathogenesis and sheds new light on targeting this pathway for diagnosis, prevention, and therapy."xsd:string |
| http://purl.uniprot.org/citations/34492536 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.intimp.2021.108066"xsd:string |
| http://purl.uniprot.org/citations/34492536 | http://purl.uniprot.org/core/author | "An J."xsd:string |
| http://purl.uniprot.org/citations/34492536 | http://purl.uniprot.org/core/author | "Zhang G."xsd:string |
| http://purl.uniprot.org/citations/34492536 | http://purl.uniprot.org/core/author | "Zhang X.L."xsd:string |
| http://purl.uniprot.org/citations/34492536 | http://purl.uniprot.org/core/author | "Xu C.Y."xsd:string |
| http://purl.uniprot.org/citations/34492536 | http://purl.uniprot.org/core/author | "Liu X.F."xsd:string |
| http://purl.uniprot.org/citations/34492536 | http://purl.uniprot.org/core/author | "Deng Y.Z."xsd:string |
| http://purl.uniprot.org/citations/34492536 | http://purl.uniprot.org/core/author | "Cui M.Y."xsd:string |
| http://purl.uniprot.org/citations/34492536 | http://purl.uniprot.org/core/author | "Bai Z.H."xsd:string |
| http://purl.uniprot.org/citations/34492536 | http://purl.uniprot.org/core/author | "Fang X.Z."xsd:string |
| http://purl.uniprot.org/citations/34492536 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34492536 | http://purl.uniprot.org/core/name | "Int Immunopharmacol"xsd:string |
| http://purl.uniprot.org/citations/34492536 | http://purl.uniprot.org/core/pages | "108066"xsd:string |
| http://purl.uniprot.org/citations/34492536 | http://purl.uniprot.org/core/title | "A novel miRNA-762/NFIX pathway modulates LPS-induced acute lung injury."xsd:string |
| http://purl.uniprot.org/citations/34492536 | http://purl.uniprot.org/core/volume | "100"xsd:string |
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