| http://purl.uniprot.org/citations/34496234 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34496234 | http://www.w3.org/2000/01/rdf-schema#comment | "Immune cells are armed with Toll-like receptors (TLRs) for sensing and responding to pathogens and other danger cues. The role of extracellular-signal-regulated kinases 1/2 (Erk1/2) in TLR signaling remains enigmatic, with both pro- and anti-inflammatory functions described. We reveal here that the immune-specific transmembrane adaptor SCIMP is a direct scaffold for Erk1/2 in TLR pathways, with high-resolution, live-cell imaging revealing that SCIMP guides the spatial and temporal recruitment of Erk2 to membrane ruffles and macropinosomes for pro-inflammatory TLR4 signaling. SCIMP-deficient mice display defects in Erk1/2 recruitment to TLR4, c-Fos activation, and pro-inflammatory cytokine production, with these effects being phenocopied by Erk1/2 signaling inhibition. Our findings thus delineate a selective role for SCIMP as a key scaffold for the membrane recruitment of Erk1/2 kinase to initiate TLR-mediated pro-inflammatory responses in macrophages."xsd:string |
| http://purl.uniprot.org/citations/34496234 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2021.109662"xsd:string |
| http://purl.uniprot.org/citations/34496234 | http://purl.uniprot.org/core/author | "Liu L."xsd:string |
| http://purl.uniprot.org/citations/34496234 | http://purl.uniprot.org/core/author | "Ingley E."xsd:string |
| http://purl.uniprot.org/citations/34496234 | http://purl.uniprot.org/core/author | "Luo L."xsd:string |
| http://purl.uniprot.org/citations/34496234 | http://purl.uniprot.org/core/author | "Schroder K."xsd:string |
| http://purl.uniprot.org/citations/34496234 | http://purl.uniprot.org/core/author | "Sweet M.J."xsd:string |
| http://purl.uniprot.org/citations/34496234 | http://purl.uniprot.org/core/author | "Condon N.D."xsd:string |
| http://purl.uniprot.org/citations/34496234 | http://purl.uniprot.org/core/author | "Stow J.L."xsd:string |
| http://purl.uniprot.org/citations/34496234 | http://purl.uniprot.org/core/author | "Curson J.E.B."xsd:string |
| http://purl.uniprot.org/citations/34496234 | http://purl.uniprot.org/core/author | "Burgener S.S."xsd:string |
| http://purl.uniprot.org/citations/34496234 | http://purl.uniprot.org/core/author | "Lucas R.M."xsd:string |
| http://purl.uniprot.org/citations/34496234 | http://purl.uniprot.org/core/author | "Das Gupta K."xsd:string |
| http://purl.uniprot.org/citations/34496234 | http://purl.uniprot.org/core/author | "Koh Y.W.H."xsd:string |
| http://purl.uniprot.org/citations/34496234 | http://purl.uniprot.org/core/author | "Tuladhar N."xsd:string |
| http://purl.uniprot.org/citations/34496234 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34496234 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/34496234 | http://purl.uniprot.org/core/pages | "109662"xsd:string |
| http://purl.uniprot.org/citations/34496234 | http://purl.uniprot.org/core/title | "SCIMP is a spatiotemporal transmembrane scaffold for Erk1/2 to direct pro-inflammatory signaling in TLR-activated macrophages."xsd:string |
| http://purl.uniprot.org/citations/34496234 | http://purl.uniprot.org/core/volume | "36"xsd:string |
| http://purl.uniprot.org/citations/34496234 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34496234 |
| http://purl.uniprot.org/citations/34496234 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34496234 |
| http://purl.uniprot.org/uniprot/#_A6H659-mappedCitation-34496234 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34496234 |
| http://purl.uniprot.org/uniprot/#_F8WHN0-mappedCitation-34496234 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34496234 |