| http://purl.uniprot.org/citations/34504050 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34504050 | http://www.w3.org/2000/01/rdf-schema#comment | "As a pancreatic inflammatory marker, regenerating islet-derived protein 3A (Reg3A) plays a key role in inflammation-associated pancreatic carcinogenesis by promoting cell proliferation, inhibiting apoptosis, and regulating cancer cell migration and invasion. This study aimed to reveal a novel immuno-regulatory mechanism by which Reg3A modulates tumour-promoting responses during pancreatic cancer (PC) progression. In an in vitro Transwell system that allowed the direct co-culture of human peripheral blood-derived dendritic cells (DCs) and Reg3A-overexpressing/ silenced human PC cells, PC cell-derived Reg3A was found to downregulate CD80, CD83 and CD86 expression on educated DCs, increase DC endocytic function, inhibit DC-induced T lymphocyte proliferation, reduce IL-12p70 production, and enhance IL-23 production by DCs. The positive effect of tumour-derived Reg3A-educated human DCs on PC progression was demonstrated in vivo by intraperitoneally transferring them into PC-implanted severe combined immunodeficiency (SCID) mice reconstituted with human T cells. A Reg3A-JAK2/STAT3 positive feedback loop was identified in DCs educated with Reg3A. In conclusion, as a tumour-derived factor, Reg3A acted to block the differentiation and maturation of the most important antigen-presenting cells, DCs, causing them to limit their potential anti-tumour responses, thus facilitating PC escape and progression."xsd:string |
| http://purl.uniprot.org/citations/34504050 | http://purl.org/dc/terms/identifier | "doi:10.14348/molcells.2021.0145"xsd:string |
| http://purl.uniprot.org/citations/34504050 | http://purl.uniprot.org/core/author | "Guo J."xsd:string |
| http://purl.uniprot.org/citations/34504050 | http://purl.uniprot.org/core/author | "Hu X."xsd:string |
| http://purl.uniprot.org/citations/34504050 | http://purl.uniprot.org/core/author | "Liao M."xsd:string |
| http://purl.uniprot.org/citations/34504050 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/34504050 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34504050 | http://purl.uniprot.org/core/name | "Mol Cells"xsd:string |
| http://purl.uniprot.org/citations/34504050 | http://purl.uniprot.org/core/pages | "647-657"xsd:string |
| http://purl.uniprot.org/citations/34504050 | http://purl.uniprot.org/core/title | "Tumour-Derived Reg3A Educates Dendritic Cells to Promote Pancreatic Cancer Progression."xsd:string |
| http://purl.uniprot.org/citations/34504050 | http://purl.uniprot.org/core/volume | "44"xsd:string |
| http://purl.uniprot.org/citations/34504050 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34504050 |
| http://purl.uniprot.org/citations/34504050 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34504050 |
| http://purl.uniprot.org/uniprot/#_Q53S56-mappedCitation-34504050 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34504050 |
| http://purl.uniprot.org/uniprot/#_L8E7R5-mappedCitation-34504050 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34504050 |
| http://purl.uniprot.org/uniprot/#_Q06141-mappedCitation-34504050 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34504050 |
| http://purl.uniprot.org/uniprot/Q06141 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/34504050 |
| http://purl.uniprot.org/uniprot/Q53S56 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/34504050 |
| http://purl.uniprot.org/uniprot/L8E7R5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/34504050 |